Description

2-Chloro-5-Iodo-3-Nitropyridine is a halogenated and nitrated pyridine derivative, a versatile and high-value chemical intermediate. Its unique substitution pattern makes it a critical building block for constructing complex molecular architectures in advanced research and development. This compound is primarily sought after by pharmaceutical, agrochemical, and material science industries for applications in medicinal chemistry, ligand synthesis, and the development of functional materials.

Application

• Pharmaceutical Intermediate: A key precursor in the synthesis of active pharmaceutical ingredients (APIs), particularly for candidates targeting central nervous system (CNS) disorders and infectious diseases.
• Agrochemical Synthesis: Used in the research and development of novel herbicides, fungicides, and insecticides, leveraging its halogenated pyridine core.
• Ligand and Catalyst Development: Serves as a starting material for creating specialized ligands used in transition metal catalysis and organometallic chemistry.
• Material Science Research: Employed in the synthesis of organic semiconductors, liquid crystals, and other functional organic materials due to its electron-deficient aromatic system.
• Chemical Biology Probes: Useful for synthesizing molecular probes and tags for studying biological processes and protein interactions.
• Cross-Coupling Reactions: The iodine and chlorine substituents make it an excellent substrate for sequential palladium-catalyzed cross-coupling reactions (e.g., Suzuki, Sonogashira).

Basic Information

Product Name	2-Chloro-5-Iodo-3-Nitropyridine
CAS No.	426463-05-0
Molecular Formula	C5H2ClIN2O2
Molecular Weight	284.44 g/mol
Synonyms	3-Nitro-2-chloro-5-iodopyridine; 2-Chloro-5-iodo-3-nitropyridine; 5-Iodo-2-chloro-3-nitropyridine; Pyridine, 2-chloro-5-iodo-3-nitro-; 426463-05-0
EINECS	Contact for details

Quality Control

Our 2-Chloro-5-Iodo-3-Nitropyridine is manufactured under strict quality control protocols to ensure batch-to-batch consistency and high purity for research and industrial use. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing key parameters such as assay, identity, and impurity profiles. Our quality management system is designed to meet the stringent requirements of our global clientele in regulated industries.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at room temperature (15-25°C). Keep away from heat, sparks, and open flame. Due to its light-sensitive nature, handling should be conducted under appropriate conditions to maintain product integrity.

Specification

Item	Specification
Appearance	Off-white to pale yellow crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 97.0%
Melting Point	Contact for details
Loss on Drying	≤ 0.5%
Related Substances (HPLC)	Individual impurity ≤ 1.0%; Total impurities ≤ 2.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.