Description

1,6-Dioxaspiro[4.5]Decane-2-Methanol,8-Ethyl-3-Hydroxy-,(2R,3S,5S,8S)-(9Ci) is a high-purity, stereochemically defined spirocyclic compound that serves as a critical chiral building block and advanced intermediate in complex organic synthesis. Its precise stereochemistry and functional group arrangement make it invaluable for constructing molecules with specific three-dimensional architectures. This compound is essential for research and development chemists in the pharmaceutical and agrochemical industries, particularly for the synthesis of novel active ingredients and fine chemicals where stereochemical control is paramount.

Application

• Pharmaceutical Intermediate: A key chiral synthon for the research and development of new active pharmaceutical ingredients (APIs), especially in therapeutic areas requiring complex molecular scaffolds.
• Agrochemical Synthesis: Used in the production of advanced, stereoselective pesticides and herbicides where biological activity is highly dependent on molecular configuration.
• Asymmetric Catalysis Ligand Precursor: Serves as a starting material for the synthesis of novel chiral ligands used in asymmetric hydrogenation and other catalytic processes.
• Fine Chemical Manufacturing: Employed in the custom synthesis of specialty chemicals, flavors, and fragrances that require high stereochemical purity.
• Academic & Industrial R&D: A valuable tool for methodological development in organic chemistry, enabling studies on stereoselective reactions and natural product synthesis.
• Material Science Research: Potential building block for creating novel chiral polymers or functional materials with specific optical properties.

Basic Information

Product Name	1,6-Dioxaspiro[4.5]Decane-2-Methanol,8-Ethyl-3-Hydroxy-,(2R,3S,5S,8S)-(9Ci)
CAS No.	415685-05-1
Molecular Formula	C11H20O4
Molecular Weight	216.27 g/mol
Synonyms	(2R,3S,5S,8S)-8-Ethyl-3-hydroxy-1,6-dioxaspiro[4.5]decane-2-methanol; 8-Ethyl-3-hydroxy-1,6-dioxaspiro[4.5]decane-2-methanol (2R,3S,5S,8S)-; (2R,3S,5S,8S)-8-Ethyl-3-hydroxy-1,6-dioxaspiro[4.5]decane-2-methanol (9CI); 1,6-Dioxaspiro[4.5]decane-2-methanol, 8-ethyl-3-hydroxy-, (2R,3S,5S,8S)-; Spirocyclic diol ether derivative; Chiral spiroketal alcohol; CAS 415685-05-1
EINECS	Contact for details

Quality Control

Our production of 1,6-Dioxaspiro[4.5]Decane-2-Methanol,8-Ethyl-3-Hydroxy-,(2R,3S,5S,8S)-(9Ci) adheres to stringent quality management protocols to ensure batch-to-batch consistency and high stereochemical purity. Each lot is fully characterized and tested using advanced analytical techniques including chiral HPLC, NMR, and MS. A comprehensive Certificate of Analysis (COA) detailing identity, purity, enantiomeric excess, and impurity profile is provided with every shipment, supporting cGMP and ISO 9001 standards for research and development use.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (typically 15-25°C). The compound may be hygroscopic; keep the container tightly sealed in a dry environment to prevent moisture absorption.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Enantiomeric Excess (Chiral HPLC)	≥ 99.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Single Unknown Impurity (HPLC)	≤ 0.5%
Total Impurities (HPLC)	≤ 2.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.