Description

tert-Butyl (1R*,4R*)-4-(Nicotinamido)Cyclohexylcarbamate is a high-purity, advanced pharmaceutical intermediate characterized by its specific stereochemistry. This compound matters for its critical role in the synthesis of complex, biologically active molecules, offering researchers and manufacturers a reliable building block with defined configuration. It is primarily needed by pharmaceutical R&D teams and fine chemical producers engaged in developing new therapeutic agents, particularly in areas requiring chiral specificity.

Application

• Pharmaceutical Intermediate: Serves as a key chiral building block in the research and development of novel active pharmaceutical ingredients (APIs).
• Protease Inhibitor Synthesis: Used in the synthetic pathways for potential protease inhibitor candidates, leveraging its nicotinamide and carbamate functionalities.
• Medicinal Chemistry Research: Employed in structure-activity relationship (SAR) studies and lead optimization processes due to its defined stereocenters.
• Peptidomimetic Development: Acts as a constrained scaffold in the design and synthesis of peptidomimetic compounds for drug discovery.
• Custom Synthesis & Contract Manufacturing: Supplied to CDMOs (Contract Development and Manufacturing Organizations) for custom synthesis projects requiring high stereochemical purity.
• Reference Standard: Can be utilized as an analytical reference standard for quality control and method development in API manufacturing.

Basic Information

Product Name	tert-Butyl (1R*,4R*)-4-(Nicotinamido)Cyclohexylcarbamate
CAS No.	412357-62-1
Molecular Formula	C17H25N3O3
Molecular Weight	319.40 g/mol
Synonyms	tert-Butyl N-[(1R,4R)-4-(pyridine-3-carboxamido)cyclohexyl]carbamate; (1R,4R)-4-[(tert-Butoxycarbonyl)amino]-N-(pyridin-3-yl)cyclohexanecarboxamide; 1,1-Dimethylethyl N-[(1R,4R)-4-[(3-pyridinylcarbonyl)amino]cyclohexyl]carbamate; BOC-(1R,4R)-4-(Nicotinamido)Cyclohexylamine; tert-Butyl (1R,4R)-4-(3-Pyridinecarboxamido)cyclohexylcarbamate
EINECS	Contact for details

Quality Control

Our tert-Butyl (1R*,4R*)-4-(Nicotinamido)Cyclohexylcarbamate is manufactured under strict quality systems. Each batch undergoes rigorous analytical testing, including chiral HPLC and NMR, to ensure high chemical and stereochemical purity compliant with cGMP standards for advanced intermediates. A comprehensive Certificate of Analysis (COA) detailing identity, purity, and impurity profiles is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). The compound may be hygroscopic; therefore, containers should be kept tightly sealed in a dry environment to prevent moisture uptake.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC)	Conforms
Identification (IR)	Conforms
Purity (HPLC)	≥ 98.0%
Chiral Purity (Chiral HPLC)	≥ 99.0% de
Water Content (KF)	≤ 0.5%
Residual Solvents (GC)	Complies with ICH Q3C

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.