Description

1,4-Dichloro 6-Carboxytetramethylrhodamine is a high-purity, functionalized derivative of the widely used tetramethylrhodamine (TAMRA) fluorophore. This compound matters for its enhanced photostability and specific reactivity, making it a critical intermediate for synthesizing advanced fluorescent probes, labels, and conjugates. It is primarily needed by research institutions, diagnostic kit manufacturers, and biotechnology companies developing assays for flow cytometry, fluorescence microscopy, and nucleic acid detection.

Application

• Fluorescent Probe Synthesis: A key building block for creating custom fluorescent probes with specific targeting capabilities.
• Biomolecule Labeling: Used to label antibodies, peptides, oligonucleotides, and other biomolecules for detection and imaging applications.
• Diagnostic Assay Development: Integral to the production of reagents for clinical diagnostics, including in-situ hybridization (FISH) and immunoassays.
• Cell Biology & Microscopy: Enables the creation of vital stains and organelle-specific dyes for live-cell and fixed-cell imaging.
• Flow Cytometry Reagents: Serves as a precursor for fluorescent dyes used in multicolor flow cytometry panels.
• Material Science Markers: Can be incorporated into polymers or nanoparticles to create traceable or functional materials.

Basic Information

Product Name	1,4-Dichloro 6-Carboxytetramethylrhodamine
CAS No.	407581-83-3
Molecular Formula	C27H22Cl2N2O5
Molecular Weight	525.38 g/mol
Synonyms	6-Carboxy-1,4-dichlorotetramethylrhodamine; 1,4-Dichloro-6-carboxy-TAMRA; 5(6)-Carboxy-1,4-dichlorotetramethylrhodamine; 6-TAMRA-COOH, dichloro derivative; TAMRA-6-COOH, 1,4-dichloro; 6-Carboxytetramethylrhodamine, 1,4-dichloro derivative; Xanthylium, 9-(2,4-dicarboxyphenyl)-3,6-bis(dimethylamino)-1,4-dichloro-, inner salt
EINECS	Contact for details

Quality Control

Our 1,4-Dichloro 6-Carboxytetramethylrhodamine is manufactured under strict quality control protocols to ensure batch-to-batch consistency and high performance in sensitive applications. Each lot is characterized by advanced analytical techniques including HPLC, NMR, and mass spectrometry. A comprehensive Certificate of Analysis (COA) detailing purity, identity, and impurity profiles is provided with every shipment to support your quality assurance and regulatory needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 15-25°C. This product is hygroscopic (moisture-sensitive) and light-sensitive; ensure the container is sealed tightly after each use to minimize exposure to atmospheric moisture and light.

Specification

Item	Specification
Appearance	Dark red to purple powder
Identification (HPLC)	Conforms
Identification (NMR)	Conforms
Purity (HPLC)	≥ 95.0%
Water Content (KF)	≤ 2.0%
Solubility	Soluble in DMSO, DMF; sparingly soluble in water

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.