Description

5-Chloro-2,3-difluoro-4-iodopyridine is a high-value, multi-halogenated pyridine derivative that serves as a critical building block in advanced organic synthesis. Its unique halogen pattern offers distinct reactivity for selective functionalization, enabling the construction of complex molecular architectures. This compound is primarily sought after by researchers and process chemists in the pharmaceutical and agrochemical industries for the development of novel active ingredients and functional materials.

Application

• Pharmaceutical Intermediate: A key precursor in the synthesis of active pharmaceutical ingredients (APIs), particularly for fluorinated drug candidates targeting CNS disorders, oncology, and anti-infectives.
• Agrochemical Synthesis: Used in the research and development of next-generation herbicides, fungicides, and insecticides, where the fluorine and iodine atoms contribute to bioavailability and environmental stability.
• Ligand and Catalyst Development: Serves as a versatile scaffold for creating novel ligands in transition metal catalysis and organocatalysis due to its electron-deficient pyridine core.
• Material Science Research: Employed in the synthesis of functionalized organic semiconductors, liquid crystals, and other advanced materials requiring halogenated heterocycles.
• Cross-Coupling Reactions: The iodine atom makes it an excellent substrate for palladium-catalyzed cross-coupling reactions (e.g., Suzuki, Sonogashira, Stille) to introduce the pyridine moiety into complex systems.
• Chemical Biology Probes: Utilized as a building block for creating molecular probes and tags for imaging and diagnostic applications.

Basic Information

Product Name	5-Chloro-2,3-difluoro-4-iodopyridine
CAS No.	406676-26-4
Molecular Formula	C5HClF2IN
Molecular Weight	290.42 g/mol
Synonyms	4-Iodo-5-chloro-2,3-difluoropyridine; 2,3-Difluoro-5-chloro-4-iodopyridine; 5-Chloro-2,3-difluoro-4-iodopyridine; Pyridine, 5-chloro-2,3-difluoro-4-iodo-; 406676-26-4
EINECS	Contact for details

Quality Control

Our 5-Chloro-2,3-difluoro-4-iodopyridine is manufactured under strict quality management systems. Every batch undergoes comprehensive analytical testing, including HPLC, GC, NMR, and mass spectrometry, to ensure identity, purity, and consistency. We provide a detailed Certificate of Analysis (COA) with each shipment, confirming compliance with agreed specifications. Our quality commitment supports your R&D and scale-up processes with reliable, high-purity material.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated place at room temperature (15-25°C). Keep away from heat, sparks, and open flame. This material is light-sensitive (store away from light).

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Related Substances (HPLC)	Total impurities ≤ 3.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.