Description

5-Chloro-2,3-difluoroisonicotinic acid is a high-purity, multi-functional heterocyclic building block of significant importance in advanced organic synthesis. Its unique halogenated pyridine core structure makes it a critical intermediate for the development of novel active pharmaceutical ingredients (APIs) and agrochemicals. This compound is primarily sought after by research institutions and manufacturers in the pharmaceutical, agrochemical, and specialty chemical industries for constructing complex molecular architectures.

Application

• Pharmaceutical Intermediate: A key precursor in the synthesis of novel drug candidates, particularly in medicinal chemistry programs targeting kinase inhibitors and other small-molecule therapeutics.
• Agrochemical Synthesis: Used in the research and development of next-generation herbicides, fungicides, and insecticides, leveraging its halogenated difluoropyridine scaffold.
• Ligand and Catalyst Development: Serves as a versatile starting material for creating specialized ligands used in transition metal catalysis and organocatalysis.
• Material Science Research: Employed in the synthesis of advanced organic materials, including liquid crystals and functional polymers, where its electronic properties are advantageous.
• Custom Synthesis and Contract Manufacturing: An essential building block for custom synthesis houses and CDMOs (Contract Development and Manufacturing Organizations) serving global clients.

Basic Information

Product Name	5-Chloro-2,3-difluoroisonicotinic Acid
CAS No.	406676-21-9
Molecular Formula	C6H2ClF2NO2
Molecular Weight	193.54 g/mol
Synonyms	5-Chloro-2,3-difluoropyridine-4-carboxylic acid; 4-Pyridinecarboxylic acid, 5-chloro-2,3-difluoro-; 5-Chloro-2,3-difluoropyridine-4-carboxylic acid; 2,3-Difluoro-5-chloroisonicotinic acid; 5-Chloro-2,3-difluoro-4-pyridinecarboxylic acid; 5-Chloro-2,3-difluoro-4-carboxypyridine; 406676-21-9 (CAS)
EINECS	Contact for details

Quality Control

Our 5-Chloro-2,3-difluoroisonicotinic acid is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity and identity confirmation via FT-IR and NMR, to ensure it meets the high standards required for research and commercial synthesis. A comprehensive Certificate of Analysis (COA) detailing all specifications is provided with every shipment to guarantee traceability and batch-to-batch consistency.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at a controlled room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed to prevent moisture absorption, which can affect stability and handling properties.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.