Description

Methyl n-Boc-4-Hydroxypiperidine-3-Carboxylate is a high-purity, protected piperidine derivative that serves as a critical chiral building block in advanced organic synthesis. This compound is essential for constructing complex molecular architectures, offering precise stereochemical control and functional group compatibility. It is primarily utilized by pharmaceutical R&D teams and fine chemical manufacturers for the development of active pharmaceutical ingredients (APIs), particularly in medicinal chemistry programs targeting neurological and metabolic disorders.

Application

• Pharmaceutical Intermediate: A key chiral synthon in the multi-step synthesis of novel drug candidates and active pharmaceutical ingredients (APIs).
• Medicinal Chemistry Research: Used in lead optimization and structure-activity relationship (SAR) studies to explore new therapeutic agents.
• Peptidomimetic Synthesis: Serves as a constrained scaffold for designing and synthesizing peptide analogs and mimetics.
• Asymmetric Synthesis: Employed as a chiral auxiliary or building block to introduce stereogenic centers in complex molecules.
• Chemical Biology Probes: Utilized in the development of molecular probes for studying enzyme mechanisms and biological pathways.
• Custom Synthesis & Contract Manufacturing: A vital starting material for CDMOs (Contract Development and Manufacturing Organizations) producing specialized fine chemicals.

Basic Information

Product Name	Methyl n-Boc-4-Hydroxypiperidine-3-Carboxylate
CAS No.	406212-51-9
Molecular Formula	C12H21NO5
Molecular Weight	259.30 g/mol
Synonyms	Methyl 4-Hydroxy-1-(tert-butoxycarbonyl)piperidine-3-carboxylate; 1-Boc-4-Hydroxy-3-piperidinecarboxylic Acid Methyl Ester; tert-Butyl 4-Hydroxy-3-(methoxycarbonyl)piperidine-1-carboxylate; 3-Carbomethoxy-4-hydroxy-1-N-Boc-piperidine; Methyl 1-N-Boc-4-hydroxypiperidine-3-carboxylate; 1-(tert-Butoxycarbonyl)-4-hydroxypiperidine-3-carboxylic Acid Methyl Ester; 4-Hydroxy-1-Boc-piperidine-3-carboxylic Acid Methyl Ester
EINECS	Contact for details

Quality Control

Our Methyl n-Boc-4-Hydroxypiperidine-3-Carboxylate is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC, NMR, and chiral purity analysis, to ensure it meets the high standards required for pharmaceutical research and development. Certificates of Analysis (COA) detailing purity, identity, and impurity profiles are provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent degradation.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Chiral Purity (Chiral HPLC)	≥ 99.0% ee
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.