Description

2-Amino-6-[2-(cyclopropylmethoxy)-6-hydroxyphenyl]-4-(4-piperidinyl)-3-pyridinecarbonitrile hydrochloride is a high-purity, non-peptidic small molecule compound of significant interest in advanced pharmaceutical research and development. This compound matters as a key chemical intermediate or reference standard for the synthesis and study of novel therapeutic agents targeting specific biological pathways. It is primarily needed by research institutions, pharmaceutical companies, and contract development and manufacturing organizations (CDMOs) engaged in drug discovery programs, particularly in areas requiring sophisticated heterocyclic chemistry.

Application

• Pharmaceutical Intermediate: Serves as a critical building block in the multi-step synthesis of potential drug candidates.
• Biochemical Research: Used as a reference standard or probe compound in enzymatic and receptor binding assays to study biological activity.
• Drug Discovery & Development: Employed in lead optimization and structure-activity relationship (SAR) studies for new chemical entities.
• Contract Manufacturing: Supplied to CDMOs for the cGMP or non-GMP production of active pharmaceutical ingredients (APIs) and advanced intermediates.
• Academic Research: Utilized in university and institutional labs for methodological development in organic synthesis and medicinal chemistry projects.

Basic Information

Item	Details
Product Name	2-Amino-6-[2-(Cyclopropylmethoxy)-6-Hydroxyphenyl]-4-(4-Piperidinyl)-3-Pyridinecarbonitrile Hydrochloride
CAS No.	406209-26-5
Molecular Formula	C21H24N4O2 · HCl
Molecular Weight	400.90 g/mol (Free base: 364.45 g/mol)
Synonyms	BMS-488043; BMS 488043; 2-Amino-6-[2-(cyclopropylmethoxy)-6-hydroxyphenyl]-4-(4-piperidinyl)-3-pyridinecarbonitrile monohydrochloride; 3-Pyridinecarbonitrile, 2-amino-6-[2-(cyclopropylmethoxy)-6-hydroxyphenyl]-4-(4-piperidinyl)-, hydrochloride (1:1); CCR5 Receptor Antagonist BMS-488043; Entry Inhibitor BMS-488043; HIV-1 Entry Inhibitor BMS-488043
EINECS	Contact for details

Quality Control

Every batch of 2-Amino-6-[2-(cyclopropylmethoxy)-6-hydroxyphenyl]-4-(4-piperidinyl)-3-pyridinecarbonitrile hydrochloride is manufactured and tested under strict quality management systems. We provide comprehensive analytical data to support research and development applications, including identity confirmation, purity assessment, and impurity profiling via advanced chromatographic and spectroscopic techniques. A detailed Certificate of Analysis (COA) is supplied with each shipment, ensuring full traceability and compliance with your project specifications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). This material is hygroscopic (moisture-sensitive) and light-sensitive; therefore, containers must be kept tightly sealed and desiccated to maintain stability and purity.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC)	Conforms to reference standard
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.5%
Heavy Metals	≤ 20 ppm
Related Substances (HPLC)	Individual impurity ≤ 0.5%; Total impurities ≤ 2.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.