Description

2,5-Dioxopyrrolidin-1-Yl 3,3,3-Trifluoropropanoate is a specialized trifluoromethyl-containing active ester reagent. This compound is a critical building block in organic synthesis, valued for its role in introducing the metabolically stable and lipophilic trifluoromethyl group into target molecules. It is primarily utilized by research and development chemists in the pharmaceutical and agrochemical industries for the synthesis of novel active ingredients and advanced intermediates.

Application

• Pharmaceutical Intermediate: A key reagent for the synthesis of active pharmaceutical ingredients (APIs) containing trifluoromethyl motifs, which are prevalent in drugs for oncology, CNS disorders, and metabolic diseases.
• Agrochemical Synthesis: Used in the development of advanced herbicides, fungicides, and insecticides where the trifluoromethyl group enhances biological activity and environmental stability.
• Peptide & Protein Modification: Serves as an acylating agent for selective modification of amino groups in peptides, proteins, and other biomolecules to study structure-activity relationships.
• Material Science Research: Employed in the creation of fluorinated polymers and advanced materials with unique surface properties, chemical resistance, and thermal stability.
• Cross-Coupling & Conjugation Chemistry: Acts as an efficient coupling reagent in amide bond formation and other conjugation reactions under mild conditions.
• Diagnostic Reagent Development: Utilized in the synthesis of fluorinated probes and contrast agents for imaging applications such as PET and MRI.

Basic Information

Item	Detail
Product Name	2,5-Dioxopyrrolidin-1-Yl 3,3,3-Trifluoropropanoate
CAS No.	405878-89-9
Molecular Formula	C7H6F3NO4
Molecular Weight	225.12 g/mol
Synonyms	3,3,3-Trifluoropropanoic Acid 2,5-Dioxo-1-pyrrolidinyl Ester; 3,3,3-Trifluoropropionic Acid N-Hydroxysuccinimide Ester; 3,3,3-Trifluoropropionic Acid NHS Ester; N-Succinimidyl 3,3,3-Trifluoropropionate; 1-[(3,3,3-Trifluoropropanoyl)oxy]-2,5-pyrrolidinedione; TFP-NHS Ester; Trifluoropropionyloxysuccinimide; 2,5-Dioxo-1-pyrrolidinyl 3,3,3-trifluoropropanoate
EINECS	Contact for details

Quality Control

Our production of 2,5-Dioxopyrrolidin-1-Yl 3,3,3-Trifluoropropanoate adheres to stringent quality protocols to ensure batch-to-batch consistency and high purity for sensitive synthetic applications. All materials undergo rigorous analytical testing, including HPLC, NMR, and MS, to confirm identity and purity. A comprehensive Certificate of Analysis (COA) detailing all specifications is provided with each shipment. We support compliance with ISO, GMP, and REACH standards for global supply.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and should be handled under anhydrous conditions to maintain stability and purity. Keep away from incompatible materials such as strong bases and oxidizing agents.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Melting Point	Contact for details
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.