Description

3-Piperidinecarboxylicacid,5-Methyl-,Methylester,(3R,5R)-(9Ci) is a high-purity, chiral piperidine derivative that serves as a critical advanced pharmaceutical intermediate. Its precise stereochemistry makes it an essential building block for the synthesis of complex active pharmaceutical ingredients (APIs), particularly in cardiovascular and metabolic disease research. This compound is primarily utilized by pharmaceutical R&D laboratories, process chemistry teams, and fine chemical manufacturers requiring a reliable source of enantiomerically pure intermediates for scale-up and production.

Application

• Pharmaceutical Intermediate: Key chiral synthon for the synthesis of statin-class drugs and other therapeutic agents targeting HMG-CoA reductase.
• Chemical Research & Development: Serves as a versatile scaffold in medicinal chemistry for creating novel compound libraries and exploring structure-activity relationships (SAR).
• Process Chemistry & Scale-Up: Used in the development and optimization of commercial-scale synthetic routes for high-value APIs.
• Asymmetric Synthesis: Employed as a chiral auxiliary or building block in stereoselective synthesis due to its defined (3R,5R) configuration.
• Reference Standard: Acts as a certified reference material (CRM) for analytical method development, validation, and quality control in pharmaceutical manufacturing.

Basic Information

Product Name	3-Piperidinecarboxylicacid,5-Methyl-,Methylester,(3R,5R)-(9Ci)
CAS No.	405513-10-2
Molecular Formula	C8H15NO2
Molecular Weight	157.21 g/mol
Synonyms	(3R,5R)-5-Methylpiperidine-3-carboxylic acid methyl ester; Methyl (3R,5R)-5-methylnipecotate; (3R,5R)-Methyl 5-methylpiperidine-3-carboxylate; (3R,5R)-5-Methyl-3-piperidinecarboxylic acid methyl ester; (3R,5R)-5-Methylnipecotic acid methyl ester; (3R,5R)-Methyl 5-methyl-3-piperidinecarboxylate; (3R,5R)-5-Methyl-3-piperidinecarboxylic acid, methyl ester; (3R,5R)-5-Methyl-3-piperidinecarboxylic acid methyl ester
EINECS	Contact for details

Quality Control

Our 3-Piperidinecarboxylicacid,5-Methyl-,Methylester,(3R,5R)-(9Ci) is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including chiral purity verification by HPLC, to ensure it meets the stringent requirements for pharmaceutical intermediate use. Certificates of Analysis (COA) detailing identity, purity, and impurity profiles are provided with every shipment to support your regulatory and quality documentation needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at controlled room temperature (15-25°C). Keep away from heat, sparks, and open flame. The container should be kept tightly sealed in a dry environment to maintain product integrity.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Chiral Purity (HPLC)	≥ 99.0% (3R,5R)
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.