Description

2-Chloro-5-Fluoro-4-Nitropyridine 1-Oxide is a high-value, multi-functional heterocyclic building block essential for advanced organic synthesis. Its unique structure, featuring halogen, nitro, and N-oxide functionalities, makes it a critical intermediate for constructing complex molecules with tailored properties. This compound is primarily sought after by research and development teams in the pharmaceutical and agrochemical industries for creating novel active ingredients and fine chemicals.

Application

• Pharmaceutical Intermediate: A key synthon for the development of novel active pharmaceutical ingredients (APIs), particularly in kinase inhibitor and antiviral drug discovery programs.
• Agrochemical Synthesis: Used in the research and production of advanced herbicides, fungicides, and insecticides, leveraging its halogenated pyridine core.
• Material Science Research: Serves as a precursor for functionalized ligands and organic electronic materials due to its electron-withdrawing substituents.
• Cross-Coupling Reactions: The chlorine and fluorine atoms provide excellent handles for palladium-catalyzed cross-coupling reactions (e.g., Suzuki, Buchwald-Hartwig) to introduce complex substituents.
• Nucleophilic Aromatic Substitution: The activated nitro and halogen groups facilitate selective displacement reactions for stepwise functionalization.
• Chemical Library Development: Employed in high-throughput and combinatorial chemistry for generating diverse compound libraries for biological screening.

Basic Information

Product Name	2-Chloro-5-Fluoro-4-Nitropyridine 1-Oxide
CAS No.	405230-80-0
Molecular Formula	C5H2ClFN2O3
Molecular Weight	192.53 g/mol
Synonyms	2-Chloro-5-fluoro-4-nitropyridine N-oxide; 4-Nitro-2-chloro-5-fluoropyridine 1-oxide; 2-Chloro-5-fluoro-4-nitropyridine 1-oxide; Pyridine, 2-chloro-5-fluoro-4-nitro-, 1-oxide; 2-Chloro-5-fluoro-4-nitropyridine N-oxide; 405230-80-0; 2-Chloro-5-fluoro-4-nitro-1-oxidopyridin-1-ium
EINECS	Contact for details

Quality Control

Every batch of 2-Chloro-5-Fluoro-4-Nitropyridine 1-Oxide is manufactured under a strict quality management system and undergoes comprehensive analytical testing to ensure identity, purity, and consistency. We provide full traceability and Certificates of Analysis (COA) are available for all shipments, detailing key parameters such as assay and impurity profiles. Our quality commitment supports your R&D and scale-up processes with reliable, high-purity material.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at a controlled room temperature (typically 15-25°C). Keep away from incompatible materials such as strong reducing agents and bases. For long-term storage, consider storing under an inert atmosphere to maintain optimal stability.

Specification

Item	Specification
Appearance	Yellow to light brown crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 97.0%
Purity (HPLC, Area%)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.