Description

Cyclopropanecarboxamide, n-[5-(4,4,5,5-Tetramethyl-1,3,2-Dioxaborolan-2-Yl)-1H-Pyrazolo[3,4-B]Pyridin-3-Yl]- is a high-value, multifunctional chemical building block that combines a pyrazolopyridine core with a pinacol boronate ester and a cyclopropanecarboxamide moiety. This compound matters for its critical role as a key synthetic intermediate in modern pharmaceutical discovery and development, particularly in the construction of complex molecules via cross-coupling reactions. It is primarily needed by R&D chemists and process development scientists in the pharmaceutical, agrochemical, and advanced materials sectors for creating novel active ingredients and functional materials.

Application

• Pharmaceutical Intermediate: Serves as a crucial building block in Suzuki-Miyaura cross-coupling reactions for synthesizing novel drug candidates, especially kinase inhibitors and other targeted therapies.
• Agrochemical Research: Used in the discovery and development of new active ingredients for crop protection, leveraging its boronate functionality for structural diversification.
• Chemical Biology & Proteomics: Employed in the synthesis of molecular probes and tool compounds for studying biological pathways and protein function.
• Material Science: Acts as a precursor for creating organic electronic materials and metal-organic frameworks (MOFs) due to its conjugated heterocyclic system and functional handles.
• Contract Research & Manufacturing (CRO/CMO): Supplied to organizations specializing in custom synthesis and scale-up services for client projects.
• Academic Research: Utilized in university and institutional laboratories for methodological development in synthetic organic chemistry and catalysis studies.

Basic Information

Product Name	Cyclopropanecarboxamide, n-[5-(4,4,5,5-Tetramethyl-1,3,2-Dioxaborolan-2-Yl)-1H-Pyrazolo[3,4-B]Pyridin-3-Yl]-
CAS No.	405224-26-2
Molecular Formula	C16H21BN4O3
Molecular Weight	328.18 g/mol
Synonyms	N-[5-(4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-yl)-1H-pyrazolo[3,4-b]pyridin-3-yl]cyclopropanecarboxamide; 3-Cyclopropanecarboxamido-5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-1H-pyrazolo[3,4-b]pyridine; 405224-26-2; Cyclopropanecarboxamide, N-[5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-1H-pyrazolo[3,4-b]pyridin-3-yl]-; 5-(4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-yl)-1H-pyrazolo[3,4-b]pyridine-3-carboxamide, N-cyclopropyl-; Boric acid, cyclic ester with N-[5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-1H-pyrazolo[3,4-b]pyridin-3-yl]cyclopropanecarboxamide
EINECS	Contact for details

Quality Control

Our Cyclopropanecarboxamide, n-[5-(4,4,5,5-Tetramethyl-1,3,2-Dioxaborolan-2-Yl)-1H-Pyrazolo[3,4-B]Pyridin-3-Yl]- is manufactured under strict quality management systems to ensure batch-to-batch consistency and reliability for sensitive synthetic applications. Each lot undergoes comprehensive analytical characterization, including HPLC for purity and NMR for structural confirmation. A detailed Certificate of Analysis (COA) is provided with every shipment, documenting all critical quality attributes. We support development from milligram to kilogram scale with a commitment to GMP-like standards where required.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and must be kept under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent degradation. For long-term storage, consider storing at 2-8°C.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥95% (Area %)
Water Content (KF)	≤1.0%
Heavy Metals	≤20 ppm
Residual Solvents (GC)	Meets ICH Q3C guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.