Description

3-(2-Oxiranyl)-1-Piperidinecarboxylic Acid 1,1-Dimethylethyl Ester is a high-purity, protected piperidine derivative featuring a reactive oxirane (epoxide) functional group. This compound serves as a critical chiral building block and advanced pharmaceutical intermediate, enabling the synthesis of complex molecules with high stereochemical fidelity. It is primarily utilized by research institutions and pharmaceutical manufacturers engaged in the development of active pharmaceutical ingredients (APIs), particularly for central nervous system (CNS) and other therapeutic agents.

Application

• Pharmaceutical Intermediate: A key chiral synthon in the multi-step synthesis of complex drug candidates and active pharmaceutical ingredients (APIs).
• Organic Synthesis Building Block: Utilized in medicinal chemistry for constructing piperidine and spirocyclic scaffolds via ring-opening reactions of the epoxide moiety.
• Asymmetric Synthesis: Employed in the development of enantiomerically pure compounds due to its defined stereochemistry, crucial for chiral drug discovery.
• Protease Inhibitor Research: Serves as a precursor in the synthesis of compounds targeting various protease enzymes.
• Chemical Biology & Probe Development: Used to create molecular probes for studying biological pathways and protein function.
• Custom Synthesis & Contract Manufacturing: Supplied to CDMOs (Contract Development and Manufacturing Organizations) for custom synthesis projects under cGMP conditions.

Basic Information

Product Name	3-(2-Oxiranyl)-1-Piperidinecarboxylic Acid 1,1-Dimethylethyl Ester
CAS No.	405087-74-3
Molecular Formula	C12H21NO3
Molecular Weight	227.30 g/mol
Synonyms	tert-Butyl 3-(oxiran-2-yl)piperidine-1-carboxylate; 1-Boc-3-(2-oxiranyl)piperidine; 1-(tert-Butoxycarbonyl)-3-(oxiran-2-yl)piperidine; 3-Epoxypropyl-1-N-Boc-piperidine; N-Boc-3-(2-Oxiranyl)piperidine; 3-(Oxiran-2-yl)piperidine-1-carboxylic acid tert-butyl ester; 1,1-Dimethylethyl 3-(2-oxiranyl)-1-piperidinecarboxylate
EINECS	Contact for details

Quality Control

Our 3-(2-Oxiranyl)-1-Piperidinecarboxylic Acid 1,1-Dimethylethyl Ester is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing to ensure identity, purity, and consistency, meeting the stringent requirements for pharmaceutical R&D and production. A comprehensive Certificate of Analysis (COA) detailing purity (typically ≥97% by HPLC), chiral purity, and impurity profiles is provided with every shipment to guarantee reliable performance in your synthetic applications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). The compound is moisture-sensitive; keep the container tightly sealed under an inert atmosphere (e.g., nitrogen or argon) for long-term storage to maintain stability and prevent degradation.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Chiral Purity (Chiral HPLC)	≥ 99.0% ee
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.