Description

Pyridine, 2-[[(4S)-4-(1,1-Dimethylethyl)-4,5-Dihydro-2-Oxazolyl]Methyl]- is a specialized chiral oxazoline-substituted pyridine derivative, serving as a high-value building block and ligand precursor in advanced organic synthesis. Its molecular architecture makes it a critical component for the development of asymmetric catalysts used in pharmaceutical and fine chemical manufacturing. This compound is primarily sought by R&D and process chemistry teams in the pharmaceutical, agrochemical, and specialty chemical industries for creating novel active ingredients and complex molecules.

Application

• Asymmetric Catalysis: As a precursor for chiral ligands in transition metal-catalyzed reactions such as hydrogenation, hydrosilylation, and cross-coupling.
• Pharmaceutical Intermediates: Key building block in the synthesis of complex, optically active drug candidates and active pharmaceutical ingredients (APIs).
• Agrochemical Synthesis: Used in the research and development of novel, enantiomerically pure herbicides, fungicides, and insecticides.
• Material Science: Potential monomer or additive for creating functional polymers and advanced materials with specific chiral properties.
• Academic & Industrial Research: A valuable tool compound for methodological development in organic and organometallic chemistry.

Basic Information

Product Name	Pyridine, 2-[[(4S)-4-(1,1-Dimethylethyl)-4,5-Dihydro-2-Oxazolyl]Methyl]-
CAS No.	404844-77-5
Molecular Formula	C14H20N2O
Molecular Weight	232.32 g/mol
Synonyms	(4S)-4-tert-Butyl-2-(2-pyridinylmethyl)-4,5-dihydrooxazole; 2-[(4S)-4-tert-Butyl-4,5-dihydro-1,3-oxazol-2-yl]methylpyridine; (S)-4-tert-Butyl-2-(pyridin-2-ylmethyl)-4,5-dihydrooxazole; (S)-2-(2-Pyridinylmethyl)-4-(1,1-dimethylethyl)-4,5-dihydrooxazole; Chiral Pyridine-Oxazoline Ligand Precursor; (S)-t-Bu-PyOx; (S)-2-(Pyridin-2-ylmethyl)-4-tert-butyl-4,5-dihydrooxazole
EINECS	Contact for details

Quality Control

Our production of this advanced intermediate adheres to strict quality protocols to ensure batch-to-batch consistency and high chiral purity, which is critical for its performance in asymmetric synthesis. Quality is verified through comprehensive analytical methods including HPLC, chiral GC/HPLC, NMR, and mass spectrometry. A detailed Certificate of Analysis (COA) is provided with each shipment, documenting identity, purity (assay), enantiomeric excess (ee), and impurity profile.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent degradation.

Specification

Item	Specification
Appearance	White to off-white crystalline powder or solid
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (Assay by HPLC)	≥ 98.0%
Enantiomeric Excess (Chiral HPLC)	≥ 99.0% ee
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.