Description

Pyridine, 2-[[(4S)-4,5-Dihydro-4-(Phenylmethyl)-2-Oxazolyl]Methyl]- is a specialized chiral oxazoline derivative, a high-value intermediate prized for its role in asymmetric synthesis. This compound matters for its ability to act as a versatile ligand or building block, enabling the production of enantiomerically pure pharmaceuticals and fine chemicals. It is primarily needed by research institutions and manufacturers in the pharmaceutical, agrochemical, and advanced materials sectors who require precise stereochemical control in their synthetic pathways.

Application

• Pharmaceutical Intermediate: A key chiral precursor in the synthesis of active pharmaceutical ingredients (APIs), particularly for central nervous system (CNS) and cardiovascular drugs.
• Asymmetric Catalysis Ligand: Used as a chiral ligand in transition metal catalysis (e.g., copper, palladium) for enantioselective C–H activation, cyclopropanation, and other carbon-heteroatom bond-forming reactions.
• Agrochemical Synthesis: Employed in the research and development of enantiomerically pure herbicides, fungicides, and plant growth regulators.
• Fine Chemical Production: Serves as a building block for complex natural products, flavors, fragrances, and advanced organic materials requiring specific stereochemistry.
• Academic & Industrial R&D: A valuable tool for chemists in method development and exploring new asymmetric synthetic routes in both university and corporate laboratory settings.

Basic Information

Product Name	Pyridine, 2-[[(4S)-4,5-Dihydro-4-(Phenylmethyl)-2-Oxazolyl]Methyl]-
CAS No.	404844-73-1
Molecular Formula	C₁₆H₁₈N₂O
Molecular Weight	254.33 g/mol
Synonyms	(4S)-4-Benzyl-2-(2-pyridinylmethyl)-4,5-dihydrooxazole; (S)-4-Benzyl-2-(pyridin-2-ylmethyl)-4,5-dihydrooxazole; 2-[(4S)-4-Benzyl-4,5-dihydro-1,3-oxazol-2-yl]methylpyridine; (S)-4-Benzyl-2-(2-pyridinylmethyl)-2-oxazoline; Chiral Pyridyl-Oxazoline Ligand; (S)-PyBox Derivative; Contact for additional trade names and abbreviations.
EINECS	Contact for details

Quality Control

Our production of this high-purity chiral intermediate adheres to strict quality management protocols. Every batch is characterized and tested to ensure identity, purity, and enantiomeric excess meet rigorous standards. Certificates of Analysis (COA) are provided, detailing results from chiral HPLC, NMR, and other analytical methods. We support compliance with cGMP and ISO 9001 standards for pharmaceutical and fine chemical applications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated place at a controlled room temperature (15-25°C). This compound is moisture-sensitive (hygroscopic) and should be handled under an inert atmosphere (e.g., nitrogen or argon) for long-term storage to prevent degradation.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Enantiomeric Excess (Chiral HPLC)	≥ 99.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.