Description

tert-Butyl n-Succinimidyl N,N'-Tetramethylenedicarbamate is a high-purity, bifunctional chemical linker and reagent designed for advanced organic synthesis and bioconjugation. This compound is valued for its role in introducing protected amine functionalities and facilitating the formation of stable amide bonds under mild conditions. It is primarily utilized by researchers and manufacturers in the pharmaceutical, biotech, and advanced materials sectors for applications such as peptide synthesis, polymer modification, and the development of antibody-drug conjugates (ADCs).

Application

• Peptide Synthesis: Acts as a key building block for introducing tert-butyloxycarbonyl (Boc)-protected diaminoalkyl spacers during solid-phase or solution-phase peptide synthesis.
• Bioconjugation & ADC Development: Used to functionalize biomolecules like antibodies or proteins with cleavable linkers, enabling the creation of targeted drug delivery systems such as Antibody-Drug Conjugates.
• Polymer & Dendrimer Modification: Serves as a cross-linking agent or functional monomer for modifying polymer backbones to introduce specific reactive sites or alter material properties.
• Protecting Group Chemistry: Provides a convenient method for the temporary protection of primary amines in multi-step synthetic routes, particularly in complex natural product synthesis.
• Diagnostic Reagent Manufacturing: Employed in the synthesis of components for diagnostic assays, including fluorescent probes and sensor molecules.
• Material Science Research: Used to create functionalized surfaces or nanoparticles for applications in catalysis, sensing, and nanotechnology.

Basic Information

Item	Details
Product Name	tert-Butyl n-Succinimidyl N,N'-Tetramethylenedicarbamate
CAS No.	404004-37-1
Molecular Formula	C15H25N3O6
Molecular Weight	343.38 g/mol
Synonyms	1,1'-(Butane-1,4-diyl)bis(3-(tert-butoxycarbonyl)urea) N-hydroxysuccinimide ester; Bis(N-succinimidyl) 4,4'-(butane-1,4-diylbis(oxycarbonylimino))dibutanoate; N,N'-Bis(Boc)-1,4-diaminobutane N-hydroxysuccinimide ester; Boc4-diamine NHS ester; (Boc)2-C4-NHS; 4,4'-((Butane-1,4-diylbis(azanediyl))bis(carbonyl))bis(oxy))bis(4-oxobutanoic acid) bis(2,5-dioxopyrrolidin-1-yl) ester tert-butyl derivative
EINECS	Contact for details

Quality Control

Our tert-Butyl n-Succinimidyl N,N'-Tetramethylenedicarbamate is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity and identity confirmation by NMR and IR spectroscopy, to ensure compliance with high-grade standards suitable for research and pharmaceutical applications. Certificates of Analysis (COA) detailing batch-specific results are available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 2-8°C or as indicated on the label. Due to its hygroscopic (moisture-sensitive) nature, the container should be kept sealed under an inert atmosphere (e.g., nitrogen or argon) when not in use to prevent degradation. Keep away from strong acids and bases.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.