Description

L-Proline, 1-Hydroxy-, Methyl Ester (9Ci) is a high-purity, non-proteinogenic amino acid derivative with a protected carboxyl group. This compound serves as a critical chiral building block in advanced organic synthesis, enabling the construction of complex molecular architectures. It is primarily required by pharmaceutical R&D and fine chemical manufacturers for the development of novel active ingredients and specialty intermediates.

Application

• Pharmaceutical Intermediate: A key chiral synthon in the synthesis of peptidomimetics, protease inhibitors, and other bioactive molecules.
• Peptide Chemistry: Used in solid-phase and solution-phase peptide synthesis to introduce modified proline residues, influencing peptide conformation and stability.
• Agrochemical Research: Employed in the development of novel herbicides and plant growth regulators with specific chiral activity.
• Bioconjugation & Probe Development: Serves as a linker or functional handle in the creation of biochemical probes and diagnostic agents.
• Academic & Industrial R&D: A valuable reagent for methodological development in asymmetric synthesis and catalysis studies.
• Cosmetic Ingredient Synthesis: Potential intermediate for synthesizing peptides used in advanced skincare formulations.

Basic Information

Product Name	L-Proline, 1-Hydroxy-, Methyl Ester (9Ci)
CAS No.	403477-63-4
Molecular Formula	C7H13NO4
Molecular Weight	175.18 g/mol
Synonyms	Methyl (2S,4R)-4-hydroxyprolinate; (4R)-Hydroxy-L-proline methyl ester; L-4-Hydroxyproline methyl ester; trans-4-Hydroxy-L-proline methyl ester; (2S,4R)-4-Hydroxypyrrolidine-2-carboxylic acid methyl ester; 1-Hydroxy-L-proline methyl ester; Methyl 4-hydroxy-L-prolinate; 403477-63-4
EINECS	Contact for details

Quality Control

Our L-Proline, 1-Hydroxy-, Methyl Ester (9Ci) is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing to ensure high chemical purity, correct stereochemistry, and consistent performance. Certificates of Analysis (COA) detailing purity, chiral purity (enantiomeric excess), and impurity profiles are provided with every shipment to support your quality assurance protocols.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This material is hygroscopic (moisture-sensitive) and should be handled in a dry environment to prevent degradation. For long-term storage, consider desiccated conditions.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Chiral Purity (HPLC)	≥ 99.0% ee
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.