Description

Hexanedioic Acid tert-Butyl Ester 2,5-Dioxopyrrolidin-1-Yl Ester is a high-purity, bifunctional chemical intermediate featuring both an active ester and a protected carboxylic acid group. This compound is critically important for its role in controlled synthesis, particularly in the formation of amide bonds under mild conditions. It is primarily needed by research and development laboratories, as well as production facilities in the pharmaceutical and advanced materials sectors, for constructing complex molecules and functional polymers.

Application

• Pharmaceutical Intermediate: Key building block for the synthesis of active pharmaceutical ingredients (APIs) and prodrugs via amide coupling reactions.
• Peptide Synthesis: Used as an activated ester reagent for the efficient and selective incorporation of adipic acid derivatives into peptide chains.
• Polymer Chemistry: Serves as a monomer or cross-linking agent in the production of specialized polyamides, polyesters, and functionalized polymers.
• Bioconjugation: Facilitates the stable attachment of small molecules, dyes, or polyethylene glycol (PEG) chains to proteins, antibodies, or other biomolecules.
• Material Science: Employed in the surface modification of nanoparticles and the creation of novel dendritic or network structures with precise functionality.
• Chemical Biology Probes: Useful for preparing labeled compounds and activity-based probes for enzymatic and cellular studies.

Basic Information

Item	Detail
Product Name	Hexanedioic Acid tert-Butyl Ester 2,5-Dioxopyrrolidin-1-Yl Ester
CAS No.	402958-62-7
Molecular Formula	C14H21NO6
Molecular Weight	299.32 g/mol
Synonyms	1-[(2,5-Dioxo-1-pyrrolidinyl)oxy]-1-oxo-6-(1,1-dimethylethoxy)-6-oxohexane; N-Hydroxysuccinimide Adipic Acid Mono-tert-butyl Ester; NHS-Adipic Acid tert-Butyl Ester; Adipic Acid Mono-tert-butyl Ester N-Hydroxysuccinimide Ester; tert-Butyl 6-((2,5-dioxopyrrolidin-1-yl)oxy)-6-oxohexanoate; Suberic Acid NHS Ester tert-Butyl Protected (common misnomer); Adipic Acid NHS Ester, tert-Butyl Protected; 6-(tert-Butoxy)-6-oxohexanoic acid 2,5-dioxopyrrolidin-1-yl ester
EINECS	Contact for details

Quality Control

Our Hexanedioic Acid tert-Butyl Ester 2,5-Dioxopyrrolidin-1-Yl Ester is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, NMR, and mass spectrometry, to ensure high chemical purity and identity. Certificates of Analysis (COA) with full specification data are available upon request to support your quality assurance and regulatory documentation needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 2-8°C or as indicated on the label. This product is hygroscopic (moisture-sensitive) and should be handled under anhydrous conditions to maintain stability and purity. Keep container tightly sealed in a desiccated environment after opening.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.