Description

4-(Cbz-Amino)-1-(Methylsulfonyl)Piperidine is a high-purity, advanced pharmaceutical intermediate featuring a piperidine scaffold protected by a carbobenzyloxy (Cbz) group and a methylsulfonyl moiety. This compound is critical for medicinal chemistry research and development, serving as a versatile building block for the synthesis of novel active pharmaceutical ingredients (APIs). It is primarily utilized by R&D chemists and process development scientists in the pharmaceutical, biotechnology, and fine chemical industries.

Application

• Pharmaceutical Intermediate: A key building block in the synthesis of complex drug candidates, particularly those targeting neurological and oncological pathways.
• Medicinal Chemistry Research: Used in structure-activity relationship (SAR) studies and lead optimization due to its modifiable functional groups.
• Peptidomimetic Synthesis: Serves as a constrained scaffold in the design and synthesis of peptide mimics for drug discovery.
• Process Chemistry Development: Employed in scaling up synthetic routes for new chemical entities (NCEs) under Good Manufacturing Practice (GMP) conditions.
• Library Synthesis for High-Throughput Screening: Used to create focused chemical libraries for biological screening against various therapeutic targets.
• Custom Synthesis and Contract Manufacturing: Supplied to CDMOs (Contract Development and Manufacturing Organizations) for custom synthesis projects.

Basic Information

Product Name	4-(Cbz-Amino)-1-(Methylsulfonyl)Piperidine
CAS No.	402927-96-2
Molecular Formula	C14H20N2O4S
Molecular Weight	312.39 g/mol
Synonyms	1-(Methylsulfonyl)-4-[(phenylmethoxy)carbonylamino]piperidine; 4-[(Benzyloxycarbonyl)amino]-1-(methylsulfonyl)piperidine; 4-(N-Cbz-amino)-1-(methylsulfonyl)piperidine; 4-Amino-1-(methylsulfonyl)piperidine N-Cbz derivative; Piperidine, 4-[[(phenylmethoxy)carbonyl]amino]-1-(methylsulfonyl)-; 4-Cbz-Amino-1-Mesyl-Piperidine; 402927-96-2; N-Cbz-4-Amino-1-methanesulfonylpiperidine
EINECS	Contact for details

Quality Control

Our 4-(Cbz-Amino)-1-(Methylsulfonyl)Piperidine is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity and identity confirmation, to ensure it meets the high standards required for pharmaceutical R&D. Certificates of Analysis (COA) with detailed chromatographic data are provided for every shipment, ensuring full traceability and compliance with your internal quality protocols.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed in a dry environment to prevent degradation. For long-term storage, consider using desiccants.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Conforms to reference
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.