Description

Glycine, n-[(2S)-2-Hydroxypropyl]-, Ethyl Ester (9Ci) is a specialized chiral amino acid derivative, specifically an ethyl ester of a hydroxypropyl-substituted glycine. This compound matters as a high-value building block for the synthesis of complex molecules, offering a unique combination of a protected carboxyl group and a chiral hydroxyl-bearing side chain. It is primarily needed by research chemists and process development scientists in the pharmaceutical and agrochemical industries for applications in peptide mimetics, prodrug development, and chiral catalyst synthesis.

Application

• Pharmaceutical Intermediate: A key chiral synthon for the research and development of novel active pharmaceutical ingredients (APIs), particularly in peptide-based therapeutics.
• Prodrug Synthesis: Utilized in designing prodrugs where the ethyl ester moiety can be cleaved enzymatically in vivo to enhance bioavailability.
• Agrochemical Research: Serves as a building block for creating chiral ligands and active compounds in crop protection agent development.
• Peptide Mimetics: Used to introduce structural modifications into peptide backbones to improve metabolic stability and receptor selectivity.
• Chiral Catalyst & Ligand Preparation: The chiral hydroxypropyl group provides a handle for constructing asymmetric catalysts used in enantioselective synthesis.
• Bioconjugation & Linker Chemistry: The functional groups allow for its use in creating specialized linkers for bioconjugation applications in diagnostics and drug delivery.

Basic Information

Product Name	Glycine, n-[(2S)-2-Hydroxypropyl]-, Ethyl Ester (9Ci)
CAS No.	402723-79-9
Molecular Formula	C7H15NO3
Molecular Weight	161.20 g/mol
Synonyms	L-2-Hydroxypropylglycine Ethyl Ester; (S)-2-(2-Hydroxypropylamino)acetic Acid Ethyl Ester; Ethyl (2S)-2-[(2-Hydroxypropyl)amino]acetate; N-[(2S)-2-Hydroxypropyl]glycine Ethyl Ester; Glycine, N-[(2S)-2-hydroxypropyl]-, ethyl ester; 402723-79-9; (S)-Ethyl 2-((2-hydroxypropyl)amino)acetate
EINECS	Contact for details

Quality Control

Our Glycine, n-[(2S)-2-Hydroxypropyl]-, Ethyl Ester (9Ci) is produced under strict quality management protocols. Each batch undergoes rigorous analytical testing, including chiral purity analysis by HPLC, to ensure high chemical and enantiomeric purity suitable for research and development. Certificates of Analysis (COA) with detailed chromatographic data are provided to guarantee traceability and batch-to-batch consistency.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at a controlled room temperature (typically 15-25°C). This material is hygroscopic (moisture-sensitive); keep the container tightly sealed under an inert atmosphere if possible to prevent degradation.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Chiral Purity (Chiral HPLC)	≥ 98.0% ee
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.