Description

(4R)-Boc-4-(2-Brombenzyl)-Pyr-Obzl CAS NO 402586-55-4 is a high-purity, advanced pharmaceutical intermediate featuring a chiral center and protective groups, making it a critical building block in modern synthetic chemistry. Its value lies in enabling the precise and efficient construction of complex, biologically active molecules, particularly in the development of targeted therapeutics. This compound is essential for research and production teams in pharmaceutical, biotechnology, and fine chemical sectors focused on creating novel active pharmaceutical ingredients (APIs) and other high-value specialty chemicals.

Application

• Pharmaceutical Intermediate: A key chiral synthon in the multi-step synthesis of novel drug candidates, particularly for central nervous system (CNS) and oncology targets.
• Peptidomimetic Research: Serves as a constrained, non-natural amino acid analog for designing and synthesizing peptide-like molecules with enhanced metabolic stability and bioavailability.
• Asymmetric Synthesis: Utilized in catalytic and stoichiometric asymmetric reactions to introduce stereochemical complexity into target molecules.
• Medicinal Chemistry & SAR Studies: Used to explore structure-activity relationships (SAR) by systematically modifying compound libraries for lead optimization.
• Contract Development and Manufacturing (CDMO): Supplied to CDMOs for the cGMP production of clinical trial materials and commercial APIs.
• Academic & Institutional Research: Employed in university and institutional labs for methodological development in organic synthesis and chemical biology.

Basic Information

Item	Details
Product Name	(4R)-Boc-4-(2-Brombenzyl)-Pyr-Obzl
CAS No.	402586-55-4
Molecular Formula	C24H28BrNO4
Molecular Weight	474.39 g/mol
Synonyms	(4R)-1-(tert-Butoxycarbonyl)-4-[(2-bromophenyl)methyl]-L-proline benzyl ester; (R)-1-Boc-4-(2-bromobenzyl)proline benzyl ester; (R)-1-N-Boc-4-(2-bromobenzyl)proline benzyl ester; Boc-(R)-4-(2-Bromobenzyl)proline-OBzl; (4R)-1-Boc-4-(2-bromobenzyl)pyrrolidine-2-carboxylic acid benzyl ester; L-Proline, 1-[(1,1-dimethylethoxy)carbonyl]-4-[(2-bromophenyl)methyl]-, phenylmethyl ester, (4R)-; Benzyl (4R)-1-[(2-methylpropan-2-yl)oxycarbonyl]-4-[(2-bromophenyl)methyl]pyrrolidine-2-carboxylate
EINECS	Contact for details

Quality Control

Every batch of (4R)-Boc-4-(2-Brombenzyl)-Pyr-Obzl is manufactured under strict quality management systems and undergoes rigorous analytical testing to ensure identity, purity, and consistency. Our standard pharmaceutical-grade material meets exacting specifications for use in critical research and development. A comprehensive Certificate of Analysis (COA) detailing chiral purity, chemical purity (by HPLC), and residual solvent levels is provided with each shipment to support your regulatory and quality documentation needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). The compound is light-sensitive; prolonged exposure to light should be avoided to maintain stability and purity. Keep the container tightly sealed in a dry environment to prevent moisture absorption.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥ 98.0%
Chiral Purity (Chiral HPLC)	≥ 99.0% ee
Related Substances (HPLC)	Total impurities ≤ 2.0% Any single impurity ≤ 1.0%
Residual Solvents (GC)	Meets ICH Q3C guidelines
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.