Description

Firategrast CAS NO 402567-16-2 is a potent and selective small molecule antagonist of the α4β1 integrin (VLA-4). This compound is of significant interest in pharmaceutical research and development due to its mechanism of action, which targets inflammatory pathways. It is primarily utilized by research institutions and pharmaceutical companies engaged in the discovery and development of novel therapeutics for autoimmune and inflammatory diseases, such as multiple sclerosis.

Application

• Pharmaceutical Intermediate: Serves as a key building block in the synthesis of active pharmaceutical ingredients (APIs) targeting inflammatory conditions.
• Biomedical Research: Used as a reference standard and a critical tool compound in preclinical studies to investigate VLA-4 mediated cell adhesion and signaling pathways.
• Drug Discovery Programs: Employed in high-throughput screening and lead optimization phases for developing new anti-inflammatory agents.
• Academic Research: Facilitates fundamental studies in immunology and the pathophysiology of autoimmune diseases.

Basic Information

Product Name	Firategrast
CAS No.	402567-16-2
Molecular Formula	C₂₀H₂₀F₂N₂O₅S
Molecular Weight	438.45 g/mol
Synonyms	SB-683699; (2S)-3-[4-({[4-(2,4-Difluorophenoxy)-1-piperidinyl]sulfonyl}methyl)phenoxy]-2-hydroxypropanoic Acid; SB 683699; SB683699; UNII-7J7I9K3H3P; 7J7I9K3H3P; Firategrast (USAN)
EINECS	Contact for details

Quality Control

Our Firategrast is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity and spectroscopic identification (NMR, MS), to ensure it meets the high standards required for research and development. Certificates of Analysis (COA) with detailed chromatographic data are provided for every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store at controlled room temperature (15-25°C) in a dry environment. For long-term storage, consider storing at -20°C under an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC)	Conforms to reference standard
Identification (IR)	Conforms to structure
Purity (HPLC)	≥98.0%
Water Content (KF)	≤0.5%
Residue on Ignition	≤0.1%
Heavy Metals	≤20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.