Description

Ethyl 5-Cyano-6-Methyl-2-Piperazinonicotinate is a high-purity, advanced pharmaceutical intermediate of significant commercial and research interest. This compound serves as a critical building block in the synthesis of complex molecules, particularly in medicinal chemistry. It is primarily sought after by pharmaceutical R&D departments and fine chemical manufacturers for the development of novel active pharmaceutical ingredients (APIs).

Application

• Pharmaceutical Intermediate: A key precursor in the synthesis of complex heterocyclic compounds and potential drug candidates.
• Medicinal Chemistry Research: Used in structure-activity relationship (SAR) studies and lead optimization for new therapeutic agents.
• API Development: Serves as a building block in the multi-step synthesis of novel Active Pharmaceutical Ingredients (APIs).
• Chemical Synthesis: Employed in academic and industrial laboratories for the construction of piperazine- and nicotinate-containing molecular frameworks.
• Contract Manufacturing: Supplied to CDMOs (Contract Development and Manufacturing Organizations) for custom synthesis projects.

Basic Information

Product Name	Ethyl 5-Cyano-6-Methyl-2-Piperazinonicotinate
CAS No.	402479-97-4
Molecular Formula	C14H18N4O2
Molecular Weight	274.32 g/mol
Synonyms	Ethyl 5-cyano-6-methyl-2-(piperazin-1-yl)nicotinate; 2-(Piperazin-1-yl)-5-cyano-6-methylnicotinic acid ethyl ester; 5-Cyano-6-methyl-2-piperazin-1-yl-nicotinic acid ethyl ester; 402479-97-4; Ethyl 5-cyano-6-methyl-2-(1-piperazinyl)-3-pyridinecarboxylate; 3-Pyridinecarboxylic acid, 5-cyano-6-methyl-2-(1-piperazinyl)-, ethyl ester
EINECS	Contact for details

Quality Control

Our Ethyl 5-Cyano-6-Methyl-2-Piperazinonicotinate is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity and identity confirmation (IR, NMR), to ensure it meets exacting standards for pharmaceutical R&D. A comprehensive Certificate of Analysis (COA) detailing all specifications is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated area at controlled room temperature (15-25°C). Keep away from incompatible materials. For long-term storage, consider an inert atmosphere to maintain optimal stability.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.