Description

trans-(4-Hydroxy-Cyclohexylmethyl)-Carbamic Acid tert-Butyl Ester is a high-purity, protected amino alcohol derivative of significant value in advanced organic synthesis. This compound serves as a critical chiral building block and versatile intermediate for constructing complex molecular architectures. It is primarily needed by research institutions and manufacturers in the pharmaceutical, agrochemical, and fine chemical industries for developing new active ingredients and specialty materials.

Application

• Pharmaceutical Intermediate: A key chiral synthon for the synthesis of novel drug candidates, particularly in central nervous system (CNS) and metabolic disease research.
• Peptidomimetics & PROTACs: Used in the construction of peptide backbones and as a linker component in Proteolysis Targeting Chimeras (PROTACs) due to its hydroxyl and protected amine functionalities.
• Agrochemical Synthesis: Serves as a precursor for developing advanced herbicides and fungicides with improved stereoselective activity.
• Ligand & Catalyst Development: Employed in the preparation of chiral ligands for asymmetric catalysis and organocatalysts.
• Polymer Modification: Acts as a functional monomer for introducing hydroxyl and latent amine groups into specialty polymers, enhancing material properties.
• Custom Synthesis & Contract Manufacturing: A valuable starting material for custom synthesis projects requiring a defined stereochemistry and orthogonal protecting groups.

Basic Information

Product Name	trans-(4-Hydroxy-Cyclohexylmethyl)-Carbamic Acid tert-Butyl Ester
CAS No.	400899-99-2
Molecular Formula	C12H23NO3
Molecular Weight	229.32 g/mol
Synonyms	tert-Butyl N-[(trans-4-hydroxycyclohexyl)methyl]carbamate; (trans-4-Hydroxycyclohexyl)methylcarbamic Acid tert-Butyl Ester; trans-4-(Boc-aminomethyl)cyclohexanol; N-Boc-trans-4-(aminomethyl)cyclohexanol; trans-N-Boc-4-Hydroxycyclohexanemethylamine; trans-4-(N-Boc-aminomethyl)cyclohexanol; (1r,4r)-4-((tert-Butoxycarbonylamino)methyl)cyclohexan-1-ol
EINECS	Contact for details

Quality Control

Our trans-(4-Hydroxy-Cyclohexylmethyl)-Carbamic Acid tert-Butyl Ester is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including chiral HPLC to confirm stereochemical purity and standard pharmacopeial identification methods. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing purity, identity, and impurity profiles to ensure compliance with your specific R&D or cGMP manufacturing requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This material is hygroscopic (moisture-sensitive) and should be handled in a dry environment to prevent degradation. For long-term storage, consider using desiccant packs in secondary containers.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Chiral Purity (Chiral HPLC)	≥ 99.0% de (trans isomer)
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.