Description

trans-(4-Hydroxymethylcyclohexyl)-Methylcarbamic Acid tert-Butyl Ester is a high-purity, advanced pharmaceutical intermediate characterized by its specific stereochemistry and protected functional groups. This compound is critical for ensuring the precise molecular architecture required in complex synthetic pathways, particularly in the development of active pharmaceutical ingredients (APIs). It is primarily utilized by research institutions and manufacturers in the pharmaceutical and fine chemical sectors for the synthesis of novel therapeutic agents.

Application

• Pharmaceutical Intermediate: A key building block in the multi-step synthesis of complex drug molecules, particularly those targeting neurological and metabolic disorders.
• Protease Inhibitor Research: Serves as a crucial precursor in the development of protease inhibitors, where its structural motif is essential for biological activity.
• Peptidomimetic Synthesis: Used to incorporate cyclohexyl and carbamate functionalities into peptidomimetic compounds, enhancing their stability and bioavailability.
• Chiral Synthesis: Provides a chiral scaffold for the asymmetric synthesis of enantiomerically pure compounds in medicinal chemistry projects.
• Chemical Biology Probes: Employed in the design and synthesis of molecular probes for studying enzyme mechanisms and cellular pathways.
• Custom Synthesis & Contract Manufacturing: Supplied to CDMOs (Contract Development and Manufacturing Organizations) for custom API synthesis under cGMP conditions.

Basic Information

Product Name	trans-(4-Hydroxymethylcyclohexyl)-Methylcarbamic Acid tert-Butyl Ester
CAS No.	400899-08-3
Molecular Formula	C14H27NO3
Molecular Weight	257.37 g/mol
Synonyms	tert-Butyl N-methyl-N-[(trans-4-(hydroxymethyl)cyclohexyl)]carbamate; (1r,4r)-4-((((tert-Butoxycarbonyl)(methyl)amino)methyl)cyclohexyl)methanol; trans-4-((N-(tert-Butoxycarbonyl)-N-methylamino)methyl)cyclohexanemethanol; BOC-N-Me-trans-4-(hydroxymethyl)cyclohexylamine; N-BOC-N-Methyl-trans-4-(aminomethyl)cyclohexanol (protected form); N-(tert-Butoxycarbonyl)-N-methyl-4-(hydroxymethyl)cyclohexylamine (trans isomer); (trans)-N-Boc-N-methyl-4-(hydroxymethyl)cyclohexanamine
EINECS	Contact for details

Quality Control

Our trans-(4-Hydroxymethylcyclohexyl)-Methylcarbamic Acid tert-Butyl Ester is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including chiral purity verification and impurity profiling, to ensure it meets the stringent requirements for pharmaceutical R&D and production. Certificates of Analysis (COA) detailing purity, identity, and related substances are provided with every shipment. We support development with custom purity grades and can align with cGMP guidelines for advanced projects.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at a controlled room temperature (15-25°C). The compound may be hygroscopic; therefore, containers should be kept sealed to minimize exposure to atmospheric moisture. For long-term storage, consider using an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥98.0%
Chiral Purity (Chiral HPLC)	≥99.0% (trans isomer)
Related Substances (HPLC)	Total impurities ≤2.0% Any single unknown impurity ≤0.5%
Water Content (KF)	≤0.5%
Residue on Ignition	≤0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.