Description

tert-Butyl 4-(1H-Pyrrolo[2,3-B]Pyridin-3-Yl)-5,6-Dihydropyridine-1(2H)-Carboxylate is a high-value, advanced pharmaceutical intermediate featuring a complex fused heterocyclic structure. This compound is critical for medicinal chemistry research and development, serving as a key building block in the synthesis of novel therapeutic agents. It is primarily utilized by pharmaceutical R&D laboratories and fine chemical manufacturers focused on developing kinase inhibitors and other targeted small-molecule drugs.

Application

• Pharmaceutical Intermediate: A crucial precursor in the multi-step synthesis of investigational new drugs, particularly in oncology and immunology research.
• Kinase Inhibitor Development: Serves as a core scaffold for designing and synthesizing potent and selective kinase inhibitors due to its privileged pyrrolopyridine-dihydropyridine structure.
• Medicinal Chemistry & SAR Studies: Used extensively in structure-activity relationship (SAR) studies to optimize drug candidate potency, selectivity, and pharmacokinetic properties.
• Process Chemistry & Scale-Up: Employed in process research and development for optimizing synthetic routes before commercial-scale GMP manufacturing.
• Contract Research & Manufacturing (CRO/CMO): Supplied to organizations specializing in custom synthesis and development services for the global biopharma industry.
• Academic Research: Used in university and institutional labs for fundamental research in heterocyclic chemistry and drug discovery methodologies.

Basic Information

Product Name	tert-Butyl 4-(1H-Pyrrolo[2,3-B]Pyridin-3-Yl)-5,6-Dihydropyridine-1(2H)-Carboxylate
CAS No.	400801-82-3
Molecular Formula	C17H21N3O2
Molecular Weight	299.37 g/mol
Synonyms	1-Boc-4-(7-azaindol-3-yl)-1,2,3,6-tetrahydropyridine; 4-(1H-Pyrrolo[2,3-b]pyridin-3-yl)-1,2,3,6-tetrahydropyridine-1-carboxylic acid tert-butyl ester; tert-Butyl 4-(1H-pyrrolo[2,3-b]pyridin-3-yl)-3,6-dihydro-1(2H)-pyridinecarboxylate; 4-(7-Azaindol-3-yl)-1-Boc-1,2,3,6-tetrahydropyridine; 1,2,3,6-Tetrahydro-4-(1H-pyrrolo[2,3-b]pyridin-3-yl)pyridine-1-carboxylic acid tert-butyl ester; 1-Boc-4-(1H-pyrrolo[2,3-b]pyridin-3-yl)-1,2,3,6-tetrahydropyridine; 3-(1-Boc-1,2,3,6-tetrahydropyridin-4-yl)-1H-pyrrolo[2,3-b]pyridine
EINECS	Contact for details

Quality Control

Our production of this advanced intermediate adheres to strict quality management systems, ensuring batch-to-batch consistency critical for pharmaceutical R&D. The material undergoes comprehensive analytical characterization, including HPLC for purity and identity confirmation via NMR and Mass Spectrometry. A detailed Certificate of Analysis (COA) is provided with each shipment, documenting key parameters such as assay purity, related substances, and residual solvents. We support development under cGMP guidelines for projects requiring regulatory filing.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed in a dry environment to prevent moisture absorption, which may affect stability and handling. For long-term storage, consider using desiccants.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC)	Conforms
Identification (MS)	Conforms
Purity (HPLC)	≥ 97.0%
Related Substances (HPLC)	Total impurities ≤ 3.0%
Any Single Unknown Impurity	≤ 0.5%
Residual Solvents (GC)	Meets ICH Q3C guidelines
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.