Description

tert-Butyl 6-(Bromomethyl)Pyridin-2-Ylcarbamate is a high-purity, advanced pharmaceutical intermediate featuring a reactive bromomethyl group and a protected amine. This compound is a critical building block in modern organic synthesis, enabling the precise construction of complex molecules. It is primarily utilized by research institutions and manufacturers in the pharmaceutical and agrochemical sectors for the development of active ingredients and novel chemical entities.

Application

• Pharmaceutical Intermediate: A key precursor in the synthesis of active pharmaceutical ingredients (APIs), particularly for kinase inhibitors and other small-molecule therapeutics.
• Agrochemical Synthesis: Used in the research and production of advanced crop protection agents and herbicides.
• Chemical Biology & Proteomics: Serves as a versatile linker or functionalization reagent for bioconjugation and probe development.
• Material Science Research: Employed in the creation of functionalized polymers and advanced organic materials.
• Cross-Coupling Reactions: The bromomethyl moiety acts as an effective handle for palladium-catalyzed cross-coupling (e.g., Suzuki, Sonogashira) to introduce complex substituents.
• Custom Synthesis & Contract Manufacturing: An essential starting material for custom synthesis projects and scale-up processes in CDMO (Contract Development and Manufacturing Organization) facilities.

Basic Information

Product Name	tert-Butyl 6-(Bromomethyl)Pyridin-2-Ylcarbamate
CAS No.	400781-16-0
Molecular Formula	C11H15BrN2O2
Molecular Weight	287.15 g/mol
Synonyms	2-Pyridinecarboxylic acid, 6-(bromomethyl)-, 1,1-dimethylethyl ester; 6-(Bromomethyl)-2-pyridinecarboxylic acid tert-butyl ester; tert-Butyl 6-(bromomethyl)picolinate; 2-(tert-Butoxycarbonyl)-6-(bromomethyl)pyridine; BOC-6-Bromomethyl Picolinate; 6-Bromomethyl-pyridine-2-carboxylic acid tert-butyl ester
EINECS	Contact for details

Quality Control

Our tert-Butyl 6-(Bromomethyl)Pyridin-2-Ylcarbamate is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, NMR, and mass spectrometry, to ensure high chemical purity and identity confirmation. Certificates of Analysis (COA) with full traceability are provided to guarantee compliance with your research or production specifications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and should be handled under inert atmosphere (e.g., nitrogen or argon) for prolonged storage or after opening to maintain stability.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.