Description

[1S-, 2R-, 5R-]3-Aza-Bicyclo[3.1.0]Hexane-2,3-Dicarboxylic Acid 3-tert-Butyl Ester is a high-purity, advanced pharmaceutical intermediate characterized by its unique, constrained bicyclic structure. This compound is a critical chiral building block for the synthesis of complex active pharmaceutical ingredients (APIs), offering precise stereochemical control. It is primarily required by research institutions and pharmaceutical manufacturers engaged in the development of novel therapeutics, particularly in the areas of central nervous system (CNS) agents and enzyme inhibitors.

Application

• Pharmaceutical Intermediate: A key chiral synthon in the multi-step synthesis of complex drug candidates and active pharmaceutical ingredients (APIs).
• Medicinal Chemistry Research: Used in lead optimization and structure-activity relationship (SAR) studies to explore new chemical entities.
• Asymmetric Synthesis: Serves as a valuable scaffold for constructing molecules with defined stereochemistry, crucial for drug efficacy and safety.
• Protease Inhibitor Development: Its structural features make it relevant for research into inhibitors targeting specific enzymes.
• Chemical Biology Probes: Utilized in the development of tool compounds for studying biological pathways and target validation.
• Custom Synthesis & Contract Manufacturing: Supplied to CDMOs (Contract Development and Manufacturing Organizations) for custom API synthesis projects.

Basic Information

Product Name	[1S-, 2R-, 5R-]3-Aza-Bicyclo[3.1.0]Hexane-2,3-Dicarboxylic Acid 3-tert-Butyl Ester
CAS No.	400720-05-0
Molecular Formula	C12H19NO4
Molecular Weight	241.28 g/mol
Synonyms	(1S,2R,5R)-3-Azabicyclo[3.1.0]hexane-2,3-dicarboxylic acid 3-tert-butyl ester; (1S,2R,5R)-3-(tert-Butoxycarbonyl)-3-azabicyclo[3.1.0]hexane-2-carboxylic acid; 3-Azabicyclo[3.1.0]hexane-2,3-dicarboxylic acid, 3-(1,1-dimethylethyl) ester, (1S,2R,5R)-; (1S,2R,5R)-3-Boc-3-azabicyclo[3.1.0]hexane-2-carboxylic acid; tert-Butyl (1S,2R,5R)-2-carboxy-3-azabicyclo[3.1.0]hexane-3-carboxylate; Bicyclic Proline Derivative; Chiral Azabicyclohexane Ester
EINECS	Contact for details

Quality Control

Our production of this advanced intermediate adheres to strict quality management systems, ensuring batch-to-batch consistency and high purity. Quality is verified through comprehensive analytical techniques including HPLC, GC, and chiral analysis. A detailed Certificate of Analysis (COA) is provided with each shipment, documenting identity, purity, and impurity profiles. We support development and commercial projects with specifications that can meet GMP guidelines for pharmaceutical starting materials.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and must be kept under dry, inert conditions to maintain stability and purity. The original container should be kept sealed in a desiccator when not in use.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Chiral Purity (Chiral HPLC)	≥ 99.0% ee
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.