Description

D-Proline, 4-Hydroxy-5-Oxo-, Methyl Ester, (4R)- (9Ci) is a high-purity, non-proteinogenic amino acid derivative characterized by its specific stereochemistry and functional groups. This compound serves as a critical chiral building block and intermediate in advanced organic synthesis, enabling the construction of complex molecules with precise stereochemical control. It is primarily utilized by research institutions and pharmaceutical companies engaged in the development of novel active pharmaceutical ingredients (APIs), peptide mimetics, and other fine chemicals where its unique structure is essential.

Application

• Pharmaceutical Intermediate: A key chiral synthon in the research and development of new therapeutic agents, particularly for protease inhibitors and other targeted therapies.
• Peptidomimetic Synthesis: Used to introduce constrained proline analogs into peptide chains to enhance metabolic stability and biological activity.
• Asymmetric Catalysis: Employed as a precursor for chiral ligands or organocatalysts in stereoselective chemical transformations.
• Biochemical Research: Serves as a standard or reagent in enzymatic studies and metabolic pathway investigations.
• Agrochemical Development: Potential intermediate in the synthesis of advanced, chiral crop protection agents.
• Academic & Industrial R&D: A valuable tool for synthetic chemists in universities and corporate labs exploring new chemical entities and methodologies.

Basic Information

Product Name	D-Proline, 4-Hydroxy-5-Oxo-, Methyl Ester, (4R)- (9Ci)
CAS No.	400626-58-6
Molecular Formula	C7H9NO4
Molecular Weight	171.15 g/mol
Synonyms	(4R)-4-Hydroxy-5-oxo-D-proline methyl ester; Methyl (4R)-4-hydroxy-5-oxo-D-prolinate; D-4-Hydroxy-5-oxoproline methyl ester; (R)-Methyl 4-hydroxy-5-oxopyrrolidine-2-carboxylate; 4-Hydroxy-5-oxo-D-proline methyl ester; Methyl 4-hydroxy-5-oxo-D-prolinate; Proline, 4-hydroxy-5-oxo-, methyl ester, D- (8CI)
EINECS	Contact for details

Quality Control

Our D-Proline, 4-Hydroxy-5-Oxo-, Methyl Ester, (4R)- (9Ci) is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including chiral purity verification by HPLC, to ensure it meets the high standards required for research and pharmaceutical applications. A comprehensive Certificate of Analysis (COA) detailing identity, purity, and impurity profiles is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (typically 15-25°C). The product is light-sensitive and should be handled and stored away from strong light sources. Keep the container tightly sealed in a dry environment to minimize exposure to moisture.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Chiral Purity (HPLC)	≥ 99.0% ee
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%
Single Unknown Impurity (HPLC)	≤ 0.5%
Total Impurities (HPLC)	≤ 2.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.