Description

5-Bromopyridin-2-Ol is a versatile brominated pyridine derivative that serves as a critical building block in advanced organic synthesis. Its unique halogenated heterocyclic structure makes it an essential intermediate for constructing complex molecules in pharmaceutical and agrochemical research. This compound is particularly valuable for medicinal chemists and process development scientists engaged in the creation of novel active ingredients, where it facilitates key coupling and functionalization reactions to introduce the bromopyridinyl moiety.

Application

• Pharmaceutical Intermediate: A key precursor in the synthesis of active pharmaceutical ingredients (APIs), particularly for kinase inhibitors and other small-molecule therapeutics.
• Agrochemical Synthesis: Used in the development of modern pesticides, herbicides, and fungicides, where the bromopyridine core contributes to biological activity.
• Ligand and Catalyst Development: Serves as a starting material for creating specialized ligands used in transition metal catalysis and coordination chemistry.
• Material Science Research: Employed in the synthesis of organic electronic materials, such as charge-transport layers or molecular components for OLEDs.
• Cross-Coupling Reactions: An excellent substrate for Suzuki, Stille, and other palladium-catalyzed cross-coupling reactions to form biaryl and heterobiaryl structures.
• Chemical Biology Probes: Utilized in the design and synthesis of molecular probes for studying biological pathways and protein function.

Basic Information

Product Name	5-Bromopyridin-2-Ol
CAS No.	49843-23-4
Molecular Formula	C5H4BrNO
Molecular Weight	174.00 g/mol
Synonyms	2-Hydroxy-5-bromopyridine; 5-Bromo-2-hydroxypyridine; 5-Bromo-2-pyridinol; 5-Bromo-2(1H)-pyridinone; 5-Bromopyridin-2(1H)-one; 5-Bromo-2-pyridone; 5-Bromopyridin-2-ol
EINECS	Contact for details

Quality Control

Our 5-Bromopyridin-2-Ol is manufactured under a strict quality management system. Each batch undergoes comprehensive analytical testing, including HPLC, GC, NMR, and mass spectrometry, to ensure identity, purity, and consistency. We provide a detailed Certificate of Analysis (COA) with every shipment, confirming compliance with agreed specifications. Our quality commitment supports applications in cGMP environments and research requiring high-purity intermediates.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated area at a controlled room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed to prevent moisture absorption. Keep away from incompatible materials.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Melting Point	140 - 144 °C
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.