Description

(3S,4S)-Ethyl 4-Methylpyrrolidine-3-Carboxylate CAS NO 49835-91-8 is a high-purity, stereochemically defined chiral building block belonging to the pyrrolidine class of compounds. This compound is a critical intermediate in the synthesis of complex pharmaceutical molecules, particularly those targeting the central nervous system and other therapeutic areas. It is essential for research and development chemists in the pharmaceutical, agrochemical, and fine chemical industries who require a reliable source of high-quality, enantiomerically pure intermediates for advanced synthesis.

Application

• Key chiral intermediate in the synthesis of active pharmaceutical ingredients (APIs) for neurological and psychiatric disorders.
• Building block for the development of novel drug candidates in medicinal chemistry research programs.
• Precursor in the synthesis of complex natural products and other bioactive molecules requiring a defined stereochemical center.
• Intermediate for the production of agrochemicals and specialty fine chemicals where stereochemistry influences biological activity.
• Starting material for the preparation of ligands and catalysts used in asymmetric synthesis.
• Reference standard for analytical method development and quality control in pharmaceutical manufacturing.

Basic Information

Product Name	(3S,4S)-Ethyl 4-Methylpyrrolidine-3-Carboxylate
CAS No.	49835-91-8
Molecular Formula	C9H17NO2
Molecular Weight	171.24 g/mol
Synonyms	Ethyl (3S,4S)-4-methylpyrrolidine-3-carboxylate; (3S,4S)-4-Methylpyrrolidine-3-carboxylic acid ethyl ester; L-threo-4-Methylpyrrolidine-3-carboxylic acid ethyl ester; (3S-cis)-4-Methyl-3-pyrrolidinecarboxylic acid ethyl ester; 49835-91-8; Ethyl 4-methylpyrrolidine-3-carboxylate (stereoisomer); Pyrrolidine-3-carboxylic acid, 4-methyl-, ethyl ester, (3S,4S)-
EINECS	Contact for details

Quality Control

Our (3S,4S)-Ethyl 4-Methylpyrrolidine-3-Carboxylate is manufactured under strict quality management systems to ensure batch-to-batch consistency and high enantiomeric purity. Each lot is supported by a comprehensive Certificate of Analysis (COA) detailing key parameters such as chiral purity, chemical purity, and residual solvents. We adhere to cGMP principles where applicable to meet the stringent requirements of our global pharmaceutical and fine chemical partners.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at a controlled room temperature (15-25°C). The product is moisture-sensitive (hygroscopic) and should be handled under an inert atmosphere to prevent degradation. Keep away from strong bases and incompatible materials.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Chiral Purity (Chiral HPLC)	≥ 99.0% ee
Water Content (KF)	≤ 0.5%
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.