Description

tert-Butyl 2-Iodoacetate is a versatile alkylating agent and a key protected intermediate in organic synthesis. Its primary value lies in its reactivity, where the iodoacetate moiety serves as an excellent electrophile for introducing the acetic acid framework under mild conditions, while the tert-butyl group provides acid-labile protection. This compound is essential for researchers and manufacturers in the pharmaceutical, agrochemical, and specialty chemical industries who require high-purity building blocks for complex molecule construction.

Application

• Pharmaceutical Intermediate: A critical building block for the synthesis of active pharmaceutical ingredients (APIs), particularly in the development of protease inhibitors and other small molecule therapeutics.
• Peptide Modification & Bioconjugation: Used to alkylate cysteine residues in peptides and proteins, enabling site-specific labeling, the creation of antibody-drug conjugates (ADCs), and protein engineering.
• Agrochemical Synthesis: Serves as a precursor in the manufacture of advanced herbicides, fungicides, and plant growth regulators.
• Material Science & Polymer Chemistry: Employed to functionalize polymers and surfaces, introducing reactive ester groups for further chemical modification.
• Organic Synthesis Reagent: Acts as a reliable electrophile in nucleophilic substitution reactions (SN2) for C-alkylation, facilitating the construction of complex carbon skeletons in fine chemical production.
• Protecting Group Strategy: The tert-butyl ester is a common protecting group for carboxylic acids, allowing for orthogonal deprotection in multi-step synthetic sequences.

Basic Information

Product Name	tert-Butyl 2-Iodoacetate
CAS No.	49827-15-8
Molecular Formula	C6H11IO2
Molecular Weight	242.06 g/mol
Synonyms	2-Iodoacetic Acid tert-Butyl Ester; tert-Butyl Iodoacetate; Acetic Acid, 2-Iodo-, 1,1-Dimethylethyl Ester; Iodoacetic Acid tert-Butyl Ester; t-Butyl 2-Iodoacetate; (tert-Butoxycarbonylmethyl)iodide; 1-(tert-Butoxy)-2-iodoethan-1-one
EINECS	Contact for details

Quality Control

Our tert-Butyl 2-Iodoacetate is manufactured under strict quality management systems. Every batch undergoes rigorous analytical testing, including HPLC, GC, and NMR, to ensure high chemical purity and consistency. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing all critical specifications. Our production adheres to cGMP principles where applicable, ensuring reliability for research and scale-up processes.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Keep away from strong acids and incompatible organic solvents. Due to its light-sensitive nature and potential for decomposition, it is recommended to use the material promptly after opening under an inert atmosphere for optimal stability.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR)	Conforms to structure
Assay (HPLC/GC)	≥ 97.0%
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.