Description

1H-Pyrrolo[2,3-B]Pyridine-3-Propanoic Acid, A-Amino-, (As)- is a high-purity, non-natural amino acid derivative featuring a fused pyrrolopyridine heterocyclic core. This compound is a critical chiral building block in modern pharmaceutical research and development, valued for its structural complexity and functional versatility. It is primarily sought after by R&D chemists and process development scientists in the pharmaceutical and biotechnology sectors for the synthesis of novel active pharmaceutical ingredients (APIs) and advanced intermediates.

Application

• Pharmaceutical Intermediate: A key chiral synthon for the synthesis of complex drug candidates, particularly in oncology and central nervous system (CNS) therapeutic areas.
• Proteolysis Targeting Chimera (PROTAC) Development: Serves as a versatile linker or warhead component in the design of targeted protein degradation molecules.
• Peptidomimetic & Macrocyclic Drug Design: Used to introduce constrained, drug-like scaffolds into peptide backbones to enhance metabolic stability and binding affinity.
• Chemical Biology & Probe Synthesis: Employed in the creation of molecular probes for studying enzyme function and biological pathways.
• Asymmetric Catalysis Ligand Precursor: Acts as a starting material for synthesizing novel chiral ligands used in asymmetric synthesis.
• Agrochemical Research: Investigated as a potential intermediate for developing new, high-performance crop protection agents with novel modes of action.

Basic Information

Product Name	1H-Pyrrolo[2,3-B]Pyridine-3-Propanoic Acid, A-Amino-, (As)-
CAS No.	49758-35-2
Molecular Formula	C10H11N3O2
Molecular Weight	205.21 g/mol
Synonyms	(αS)-α-Amino-1H-pyrrolo[2,3-b]pyridine-3-propanoic acid; (S)-2-Amino-3-(1H-pyrrolo[2,3-b]pyridin-3-yl)propanoic acid; (S)-3-(1H-Pyrrolo[2,3-b]pyridin-3-yl)alanine; L-3-(1H-Pyrrolo[2,3-b]pyridin-3-yl)alanine; 7-Azatryptophan; 7-Aza-L-tryptophan; Tryptazan (7-aza analog); 1H-Pyrrolo[2,3-b]pyridine-3-propanoic acid, α-amino-, (αS)-
EINECS	Contact for details

Quality Control

Our production of 1H-Pyrrolo[2,3-B]Pyridine-3-Propanoic Acid, A-Amino-, (As)- adheres to stringent quality management protocols. Every batch undergoes comprehensive analytical testing, including chiral purity verification, to ensure compliance with research and cGMP-grade standards for pharmaceutical applications. Certificates of Analysis (COA) detailing identity, purity, chiral excess, and impurity profiles are provided with each shipment and are available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and should be handled under a dry atmosphere to prevent degradation. For long-term storage, consider storing under an inert gas such as argon or nitrogen.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥ 98.0%
Chiral Purity (Chiral HPLC)	≥ 99.0% ee
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.