Description

1-(Trimethylsilyl)-1H-Benzotriazole is a versatile organosilicon-protected benzotriazole derivative, primarily utilized as a key synthetic intermediate and protecting group reagent. Its value lies in its ability to act as a masked benzotriazole anion, facilitating nucleophilic substitution reactions under mild conditions. This compound is essential for researchers and manufacturers in the pharmaceutical, agrochemical, and advanced materials sectors, where it is used in the synthesis of complex molecules, heterocyclic compounds, and functional polymers.

Application

• Pharmaceutical Intermediate: A crucial building block in the synthesis of active pharmaceutical ingredients (APIs) and novel drug candidates.
• Agrochemical Synthesis: Used in the production of herbicides, fungicides, and other crop protection agents.
• Polymer & Material Science: Serves as a monomer or functionalization agent in the development of specialty polymers and advanced materials.
• Organic Synthesis Reagent: Acts as a protected benzotriazole anion equivalent for nucleophilic alkylation and arylation reactions.
• Ligand & Catalyst Preparation: Employed in the synthesis of N-heterocyclic carbene (NHC) precursors and other catalytic ligands.
• Research & Development: A valuable tool for medicinal chemistry and process chemistry research in academic and industrial laboratories.

Basic Information

Product Name	1-(Trimethylsilyl)-1H-Benzotriazole
CAS No.	48183-36-4
Molecular Formula	C9H13N3Si
Molecular Weight	191.31 g/mol
Synonyms	1-(Trimethylsilyl)benzotriazole; Benzotriazole, 1-(trimethylsilyl)-; 1H-Benzotriazole, 1-(trimethylsilyl)-; TMS-Bt; N-Trimethylsilylbenzotriazole; 1-Trimethylsilylbenzotriazole; 1-TMS-benzotriazole; 1-(TMS)-1H-benzotriazole
EINECS	Contact for details

Quality Control

Our 1-(Trimethylsilyl)-1H-Benzotriazole is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC, GC, and NMR, to ensure high purity and consistency. Certificates of Analysis (COA) detailing identity, purity, and impurity profiles are provided with every shipment to support your quality assurance and regulatory needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at room temperature (15-25°C). This material is hygroscopic (moisture-sensitive) and should be handled under an inert atmosphere (e.g., nitrogen or argon) to prevent degradation. Keep away from strong acids and oxidizing agents.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Melting Point	85 - 90 °C
Loss on Drying	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.