Description

Nornalmefene is a specialized pharmaceutical intermediate and research chemical with significant importance in the development of opioid receptor antagonists. This compound is valued for its role in medicinal chemistry research and the synthesis of advanced therapeutic agents. It is primarily utilized by pharmaceutical R&D laboratories, academic research institutions, and fine chemical manufacturers targeting the development of treatments for substance use disorders and pain management.

Application

• Pharmaceutical Intermediate: A key building block in the synthesis of opioid antagonist drug candidates and related analogs.
• Medicinal Chemistry Research: Used in structure-activity relationship (SAR) studies to explore and optimize pharmacological profiles.
• Reference Standard: Serves as a high-purity analytical standard for quality control and method development in pharmaceutical analysis.
• Biochemical Research: Employed in vitro studies to investigate interactions with opioid receptor subtypes (e.g., μ, κ, δ).
• Preclinical Development: Utilized in the formulation and testing of novel therapeutic entities in early-stage drug discovery pipelines.

Basic Information

Product Name	Nornalmefene
CAS No.	42971-33-5
Molecular Formula	C21H25NO4
Molecular Weight	355.43 g/mol
Synonyms	17-(Cyclopropylmethyl)-4,5α-epoxy-6-methylenemorphinan-3,14-diol; 6-Desoxy-6-methylenenaltrexone; Nor-6-methylenenaltrexone; 6-Methylenenoroxymorphone; Nor-Methylnaltrexone; Cyclopropylnoroxymorphone methylene derivative
EINECS	Contact for details

Quality Control

Our Nornalmefene is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity determination and spectroscopic methods for structural confirmation, to ensure it meets the stringent requirements for pharmaceutical research. Certificates of Analysis (COA) detailing all specifications are provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at a controlled room temperature (15-25°C). Keep the container tightly sealed to protect from moisture.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to reference spectrum
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥ 98.0%
Related Substances (HPLC)	Total impurities ≤ 2.0%
Any single unknown impurity	≤ 0.5%
Residual Solvents (GC)	Complies with ICH Q3C guidelines
Loss on Drying	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.