Description

2,2-Bis(Trimethylsiloxy)Malonic Acid Bis(Trimethylsilyl) Ester is a highly functionalized, silyl-protected derivative of malonic acid, serving as a versatile and reactive synthetic intermediate. Its core value lies in its ability to act as a masked malonate equivalent, enabling complex carbon-carbon bond formation and the introduction of silyl protecting groups under mild conditions. This compound is essential for researchers and manufacturers in pharmaceutical development, agrochemical synthesis, and advanced material science, where precise molecular construction is paramount.

Application

• Pharmaceutical Intermediate: Key building block for the synthesis of active pharmaceutical ingredients (APIs), particularly in constructing complex carboxylic acid derivatives and heterocyclic compounds.
• Agrochemical Synthesis: Used in the production of advanced pesticides and herbicides, leveraging its reactivity for creating specific bioactive molecular frameworks.
• Organic Synthesis Reagent: Acts as a protected malonyl synthon in aldol, Michael addition, and Knoevenagel condensation reactions for fine chemical production.
• Material Science Precursor: Employed in the development of specialty polymers, silicon-containing hybrid materials, and surface modification agents.
• Cross-Coupling Reactions: Serves as a substrate in palladium-catalyzed and other metal-mediated coupling reactions to form complex organic structures.
• Protecting Group Chemistry: Utilized for the temporary protection of diacid or diol functionalities during multi-step synthetic sequences.

Basic Information

Product Name	2,2-Bis(Trimethylsiloxy)Malonic Acid Bis(Trimethylsilyl) Ester
CAS No.	42827-95-2
Molecular Formula	C14H34O5Si4
Molecular Weight	410.78 g/mol
Synonyms	Malonic Acid, 2,2-Bis(trimethylsiloxy)-, Bis(trimethylsilyl) Ester; 2,2-Bis(trimethylsiloxy)malonic Acid Bis-O,O-(trimethylsilyl) Ester; Bis(trimethylsilyl) 2,2-Bis(trimethylsiloxy)malonate; Tetrakis(trimethylsilyl) Malonate; Malonic Acid Tetrakis(trimethylsilyl) Ester; TMS Malonate Derivative; 42827-95-2; Malonate Silyl Ester
EINECS	Contact for details

Quality Control

Our 2,2-Bis(Trimethylsiloxy)Malonic Acid Bis(Trimethylsilyl) Ester is produced under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, GC, and NMR, to ensure high chemical purity and consistency. A comprehensive Certificate of Analysis (COA) detailing identity, purity, and impurity profiles is provided with every shipment to support your quality assurance and regulatory compliance needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent degradation.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR)	Conforms to structure
Purity (GC/HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.