Description

n-Methylleucin-tert-Butylester is a protected amino acid derivative, specifically an N-methylated leucine with a tert-butyl ester group. This compound is a crucial chiral building block in organic synthesis, valued for its role in modulating peptide properties and enhancing metabolic stability. It is primarily utilized by pharmaceutical researchers and fine chemical manufacturers for the development of novel therapeutic peptides, peptidomimetics, and active pharmaceutical ingredients (APIs).

Application

• Pharmaceutical Intermediate: Key building block in the synthesis of peptide-based drugs and complex organic molecules.
• Peptidomimetics Research: Used to create modified peptide structures with improved bioavailability and stability.
• Solid-Phase Peptide Synthesis (SPPS): Serves as a protected amino acid derivative for the controlled assembly of peptide chains.
• Medicinal Chemistry: Employed in structure-activity relationship (SAR) studies to explore new bioactive compounds.
• Asymmetric Synthesis: Acts as a chiral auxiliary or starting material in stereoselective chemical reactions.
• Bioconjugation: Can be used to introduce specific functional groups into biomolecules for labeling or linking.

Basic Information

Product Name	n-Methylleucin-tert-Butylester
CAS No.	42807-86-3
Molecular Formula	C11H23NO2
Molecular Weight	201.31 g/mol
Synonyms	tert-Butyl N-methyl-L-leucinate; L-Leucine, N-methyl-, 1,1-dimethylethyl ester; N-Methyl-L-leucine tert-butyl ester; (S)-2-((tert-Butoxycarbonyl)(methyl)amino)-4-methylpentanoic acid; Boc-N-Me-Leu-OH; N-Methylleucine tert-butyl ester; (S)-tert-Butyl 2-(methylamino)-4-methylpentanoate
EINECS	Contact for details

Quality Control

Our n-Methylleucin-tert-Butylester is produced under strict quality management systems. Each batch undergoes comprehensive analytical testing, including chiral purity verification and impurity profiling, to ensure it meets the high standards required for pharmaceutical research and development. Certificates of Analysis (COA) detailing specific results for identity, purity, and related substances are provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed to exclude moisture. Keep away from strong acids and incompatible materials such as strong oxidizing agents.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥98.0%
Chiral Purity (HPLC)	≥99.0% ee
Water Content (KF)	≤0.5%
Residue on Ignition	≤0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.