Description

7-Chloro-5-(2-Chlorophenyl)-1,3-Dihydro-2H-Pyrido[3,2-B]-1,4-Diazepin-2-One 4-Oxide is a high-purity, advanced pharmaceutical intermediate of significant commercial and research interest. This compound is valued for its role as a key synthetic precursor in the development of active pharmaceutical ingredients (APIs), particularly within the benzodiazepine analog class. It is primarily sought by pharmaceutical R&D laboratories, fine chemical manufacturers, and academic research institutions engaged in medicinal chemistry and new drug development.

Application

• Pharmaceutical Intermediate: A critical building block in the synthesis of novel benzodiazepine-derived therapeutic agents.
• Medicinal Chemistry Research: Used in structure-activity relationship (SAR) studies to develop new central nervous system (CNS) active compounds.
• Reference Standard: Serves as a certified reference material (CRM) for analytical method development and quality control in API manufacturing.
• Process Chemistry: Employed in route scouting and optimization for scalable GMP production of target molecules.
• Biochemical Research: Utilized as a ligand or probe in pharmacological studies targeting specific receptor subtypes.
• Custom Synthesis: A starting material for the contract synthesis of specialized, non-commercially available chemical entities for clients.

Basic Information

Product Name	7-Chloro-5-(2-Chlorophenyl)-1,3-Dihydro-2H-Pyrido[3,2-B]-1,4-Diazepin-2-One 4-Oxide
CAS No.	42785-23-9
Molecular Formula	C₁₅H₁₀Cl₂N₂O₂
Molecular Weight	321.16 g/mol
Synonyms	7-Chloro-5-(2-chlorophenyl)-1,3-dihydro-2H-1,4-benzodiazepin-2-one 4-oxide; 2H-Pyrido[3,2-b][1,4]diazepin-2-one, 7-chloro-5-(2-chlorophenyl)-1,3-dihydro-, 4-oxide; 5-(2-Chlorophenyl)-7-chloro-1,3-dihydro-2H-1,4-benzodiazepin-2-one 4-oxide; 7-Chloro-5-(o-chlorophenyl)-1,3-dihydro-2H-1,4-benzodiazepin-2-one 4-oxide; Desmethyldiazepam N-Oxide Impurity; Diazepam N-Oxide Related Compound
EINECS	Contact for details

Quality Control

Our production of this advanced intermediate adheres to stringent quality systems suitable for pharmaceutical applications. Every batch is subjected to comprehensive analytical testing, including HPLC for purity and identity confirmation and residual solvent analysis. A detailed Certificate of Analysis (COA) is provided with each shipment, documenting compliance with agreed specifications. We support cGMP standards for manufacturing and can supply material suitable for use in regulatory filings.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). The compound is light-sensitive (store away from light) and may be hygroscopic (moisture-sensitive); therefore, containers should be kept sealed under an inert atmosphere if specified for long-term storage.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥ 98.0%
Related Substances (HPLC)	Total impurities ≤ 2.0%
Single Maximum Unknown Impurity	≤ 0.5%
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.