Description

17,20,21-Tris[(Trimethylsilyl)Oxy]Pregna-4,20-Diene-3,11-Dione is a key protected steroid derivative, specifically a silyl ether derivative of a pregnane-dione, which serves as a critical synthetic intermediate in advanced organic chemistry. Its primary value lies in its role as a versatile building block for the synthesis of complex steroid-based pharmaceuticals and fine chemicals, offering chemists a protected functional group strategy to enable selective downstream reactions. This compound is essential for research and development laboratories, as well as production facilities, focused on creating novel therapeutic agents, particularly in the fields of endocrinology and oncology.

Application

• Pharmaceutical Intermediate: A crucial precursor in the multi-step synthesis of high-value steroid drugs and active pharmaceutical ingredients (APIs).
• Research & Development: Used in medicinal chemistry for the discovery and structural modification of new steroid-based therapeutic candidates.
• Process Chemistry: Employed in scale-up and optimization of synthetic routes for steroid manufacturing under GMP conditions.
• Fine Chemical Synthesis: Serves as a specialized building block for synthesizing complex molecules in agrochemical and material science research.
• Reference Standard: Can be utilized as an analytical standard for quality control and method development in pharmaceutical analysis.

Basic Information

Product Name	17,20,21-Tris[(Trimethylsilyl)Oxy]Pregna-4,20-Diene-3,11-Dione
CAS No.	42599-97-3
Molecular Formula	C30H52O5Si3
Molecular Weight	577.0 g/mol
Synonyms	Pregna-4,20-diene-3,11-dione, 17,20,21-tris[(trimethylsilyl)oxy]-; 17,20,21-Tris-O-(trimethylsilyl)pregna-4,20-diene-3,11-dione; 3,11-Dioxopregna-4,20-diene-17,20,21-triyl tris(trimethylsilyl) ether; Tris(trimethylsilyl) Ether of 17,20,21-Trihydroxypregna-4,20-diene-3,11-dione; TMS-protected Pregnadienedione Derivative
EINECS	Contact for details

Quality Control

Our 17,20,21-Tris[(Trimethylsilyl)Oxy]Pregna-4,20-Diene-3,11-Dione is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity and identity confirmation by NMR and IR spectroscopy, to ensure it meets the stringent requirements for advanced synthetic intermediates. A detailed Certificate of Analysis (COA) is provided with every shipment, documenting all critical quality attributes.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed in a dry environment to prevent degradation. For long-term storage, consider using desiccants.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Conforms to reference
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.