Description

Triethyl 4-Phosphonocrotonate is a high-purity organophosphorus compound, specifically a phosphonate ester, serving as a critical Horner-Wadsworth-Emmons (HWE) reagent in advanced organic synthesis. Its primary value lies in enabling the stereoselective formation of α,β-unsaturated esters and other complex olefins, which are key intermediates in pharmaceutical and agrochemical development. This reagent is essential for research chemists and process development scientists in the fine chemical, pharmaceutical, and advanced material sectors who require reliable, high-yielding synthetic building blocks.

Application

• Pharmaceutical Intermediate Synthesis: A key reagent in the Horner-Wadsworth-Emmons olefination for constructing complex drug molecules and bioactive compounds.
• Agrochemical Production: Used in the synthesis of advanced pesticide and herbicide intermediates requiring specific alkene geometries.
• Fine Chemical Manufacturing: Employed in the production of specialty chemicals, flavors, and fragrances where precise control over double bond formation is critical.
• Material Science Research: Acts as a building block in the synthesis of functionalized polymers and organic electronic materials.
• Academic & R&D Laboratories: A staple reagent for methodological development in organic chemistry and the synthesis of novel molecular architectures.

Basic Information

Product Name	Triethyl 4-Phosphonocrotonate
CAS No.	42516-28-9
Molecular Formula	C10H19O5P
Molecular Weight	250.23 g/mol
Synonyms	Triethyl (E)-4-phosphonocrotonate; (E)-Triethyl 4-phosphonocrotonate; Diethyl [(1E)-3-ethoxy-1-propen-1-yl]phosphonate; (E)-Diethyl (3-ethoxy-1-propenyl)phosphonate; Triethyl phosphonocrotonate; 4-Phosphonocrotonic acid triethyl ester; HWE Reagent for crotonate; EINECS 255-874-0
EINECS	255-874-0

Quality Control

Our Triethyl 4-Phosphonocrotonate is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including NMR, HPLC, and GC analysis, to ensure high chemical purity and isomeric consistency. A detailed Certificate of Analysis (COA) is provided with every shipment, confirming compliance with agreed specifications. We support cGMP and ISO 9001 standards for pharmaceutical and industrial applications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated area at room temperature (15-25°C). Keep away from strong bases and incompatible materials. For long-term storage, consider maintaining under an inert atmosphere to preserve optimal reactivity.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Isomeric Purity (E-isomer)	≥ 95.0%
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.