Description

Nimustine CAS NO 42471-28-3 is a nitrosourea-based alkylating agent widely recognized for its potent antineoplastic activity. This compound is critical for pharmaceutical research and development, particularly in the field of oncology, due to its mechanism of action in inhibiting DNA synthesis and repair. It is primarily utilized by pharmaceutical manufacturers, research institutions, and academic laboratories engaged in the development and study of chemotherapeutic agents for treating various cancers, including brain tumors and hematological malignancies.

Application

• Active Pharmaceutical Ingredient (API) in the formulation of chemotherapeutic drugs.
• Oncology Research for studying the mechanisms of alkylating agents and DNA damage response.
• Preclinical Development of novel cancer therapies and combination treatment regimens.
• Reference Standard for quality control and analytical method development in pharmaceutical laboratories.
• Biochemical Research investigating cell cycle arrest and apoptosis in cancer cell lines.

Basic Information

Product Name	Nimustine
CAS No.	42471-28-3
Molecular Formula	C₉H₁₃ClN₆O₂
Molecular Weight	272.69 g/mol
Synonyms	ACNU; Nidran; 1-(4-Amino-2-methyl-5-pyrimidinyl)methyl-3-(2-chloroethyl)-3-nitrosourea; 3-[(4-Amino-2-methyl-5-pyrimidinyl)methyl]-1-(2-chloroethyl)-1-nitrosourea; 1-(2-Chloroethyl)-3-[(4-amino-2-methyl-5-pyrimidinyl)methyl]-1-nitrosourea; Nitrumon; Pimustine
EINECS	Contact for details

Quality Control

Our Nimustine is manufactured under strict quality management systems to ensure high purity and batch-to-batch consistency, suitable for research and pharmaceutical applications. Each batch is accompanied by a comprehensive Certificate of Analysis (COA) detailing purity, identity, and impurity profiles. We adhere to relevant industry guidelines to support our clients' regulatory and compliance requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (typically 15-25°C). This product is hygroscopic (moisture-sensitive) and should be handled in a dry environment to maintain stability.

Specification

Item	Specification
Appearance	White to pale yellow crystalline powder
Identification (IR)	Conforms to reference spectrum
Assay (HPLC)	≥ 98.0%
Related Substances (HPLC)	Total impurities ≤ 2.0%
Loss on Drying	≤ 1.0%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.