Description

5'-Cyanonicotine is a specialized chemical intermediate, a derivative of nicotine with a cyano group at the 5' position. This structural modification makes it a valuable precursor for the synthesis of novel nicotinic analogs and pharmacologically active compounds. It is primarily utilized by research institutions and pharmaceutical development companies engaged in medicinal chemistry and neuroscience research. The compound is supplied to meet the stringent purity requirements of advanced synthetic applications.

Application

• Key intermediate in the synthesis of novel nicotinic acetylcholine receptor (nAChR) ligands for research.
• Precursor for the development of radiolabeled probes and tracers used in neurobiological studies.
• Building block in medicinal chemistry programs targeting neurological disorders.
• Starting material for creating metabolites and analogs of nicotine for toxicological and metabolic profiling.
• Used in academic and industrial research exploring structure-activity relationships (SAR) of nicotine derivatives.

Basic Information

Product Name	5'-Cyanonicotine
CAS No.	42459-12-1
Molecular Formula	C11H13N3
Molecular Weight	187.24 g/mol
Synonyms	5'-Cyano-nicotine; Nicotine-5'-carbonitrile; 3-[(2S)-1-Methyl-2-pyrrolidinyl]pyridine-5-carbonitrile; (S)-5-Cyanonicotine; 5-Cyanopyridyl nicotine; 5-CN-Nicotine
EINECS	Contact for details

Quality Control

Our 5'-Cyanonicotine is produced under controlled conditions to ensure high chemical purity and lot-to-lot consistency, suitable for sensitive research applications. All batches undergo comprehensive analytical characterization, including HPLC, NMR, and mass spectrometry. A Certificate of Analysis (COA) detailing purity, identity, and impurity profiles is provided with each shipment to support your quality assurance protocols.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at controlled room temperature (15-25°C). Keep the container tightly sealed in a dry environment to maintain stability.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Related Substances (HPLC)	Total impurities ≤ 3.0%
Residual Solvents (GC)	Meets ICH guidelines
Specific Rotation	Contact for details

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.