Description

L-Proline, 1-Methyl-5-Oxo-, Methyl Ester (9Ci) is a high-purity, non-proteinogenic proline derivative. This compound serves as a versatile and critical chiral building block in advanced organic synthesis, enabling the construction of complex molecular architectures. It is essential for research and development in the pharmaceutical, agrochemical, and specialty chemical industries, where precise stereochemistry and functional group compatibility are paramount.

Application

• Pharmaceutical Intermediate: A key chiral synthon for the synthesis of peptidomimetics, protease inhibitors, and other active pharmaceutical ingredients (APIs).
• Agrochemical Research: Used in the development of novel herbicides, fungicides, and plant growth regulators with specific stereochemical requirements.
• Peptide Chemistry: Employed in the synthesis of modified peptides and peptide analogs to study structure-activity relationships and enhance metabolic stability.
• Asymmetric Synthesis: Acts as a precursor or auxiliary in catalytic asymmetric reactions to introduce chiral centers with high enantiomeric excess.
• Biochemical Research: Utilized as a substrate or inhibitor in enzymatic studies, particularly those involving proline-specific enzymes.
• Fine Chemical Production: Serves as a building block for flavors, fragrances, and other high-value specialty chemicals.

Basic Information

Product Name	L-Proline, 1-Methyl-5-Oxo-, Methyl Ester (9Ci)
CAS No.	42435-88-1
Molecular Formula	C7H11NO3
Molecular Weight	157.17 g/mol
Synonyms	Methyl 1-methyl-5-oxo-L-prolinate; (S)-1-Methyl-5-oxopyrrolidine-2-carboxylic acid methyl ester; L-1-Methyl-5-oxoproline methyl ester; Methyl (S)-1-methyl-5-oxopyrrolidine-2-carboxylate; 1-Methyl-L-pyroglutamic acid methyl ester; 1-Methyl-5-oxo-L-proline methyl ester; 42435-88-1; Methyl 1-methyl-5-oxo-L-prolinate (9CI)
EINECS	Contact for details

Quality Control

Our L-Proline, 1-Methyl-5-Oxo-, Methyl Ester (9Ci) is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including chiral purity assessment by HPLC, to ensure it meets the high standards required for research and synthesis. Certificates of Analysis (COA) detailing identity, purity, and impurity profiles are provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated area at controlled room temperature (15-25°C). This material is hygroscopic (moisture-sensitive); keep the container tightly sealed under an inert atmosphere to prevent degradation.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Enantiomeric Purity (Chiral HPLC)	≥ 99.0% ee
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.