Description

Trimethylsilyl-D(+)Trehalose is a chemically modified derivative of the natural disaccharide D-(+)-trehalose, where hydroxyl groups are protected by trimethylsilyl (TMS) groups. This modification is critical for its primary role as a key synthetic intermediate in organic and medicinal chemistry, enabling precise chemical transformations while protecting the sensitive sugar scaffold. It is an essential building block for researchers and manufacturers in the pharmaceutical, biotechnology, and fine chemical sectors, particularly for developing novel glycoconjugates, prodrugs, and advanced materials.

Application

• Pharmaceutical Intermediate: Serves as a protected precursor in the synthesis of complex glycoconjugates, prodrugs, and active pharmaceutical ingredients (APIs).
• Carbohydrate Chemistry Research: A vital reagent for the stepwise synthesis and modification of oligosaccharides and other sugar-based molecules in academic and industrial R&D.
• Bioconjugation & Labeling: Used to introduce trehalose motifs into biomolecules (e.g., proteins, peptides) for stability enhancement or targeted delivery applications.
• Fine Chemical Synthesis: Employed in the production of specialty chemicals, surfactants, and ligands where a protected sugar moiety is required.
• Material Science: Potential use in creating advanced polymeric materials or coatings with specific hydrophilic properties.

Basic Information

Product Name	Trimethylsilyl-D(+)Trehalose
CAS No.	42390-78-3
Molecular Formula	C24H52O11Si4
Molecular Weight	609.0 g/mol (approx.)
Synonyms	D-(+)-Trehalose, Trimethylsilyl Derivative; Per-O-trimethylsilyl-D-trehalose; α,α-Trehalose, octakis(trimethylsilyl) ether; TMS-Trehalose; Trimethylsilyl ether of Trehalose; Hexakis-O-(trimethylsilyl)-α,α-trehalose (common for partially protected forms); Octakis(trimethylsilyl)-α-D-glucopyranosyl α-D-glucopyranoside; Trehalose TMS ether
EINECS	Contact for details

Quality Control

Our Trimethylsilyl-D(+)Trehalose is produced under strict quality management protocols. Each batch undergoes comprehensive analytical testing, including HPLC for purity and identity confirmation by NMR and IR spectroscopy, to ensure it meets the high standards required for synthetic applications. A detailed Certificate of Analysis (COA) is provided with every shipment, documenting critical parameters such as assay, moisture content, and residual solvents.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed in a dry environment to prevent degradation. For long-term storage, consider using desiccants or an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white powder or solid
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 95.0%
Moisture (KF)	≤ 1.0%
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.