Description

4-Azidocoumarin is a specialized heterocyclic organic compound that serves as a versatile photoaffinity labeling reagent and a key building block in bioorthogonal chemistry. Its value lies in its unique azide functional group, which enables highly selective "click" reactions under mild conditions for tagging and crosslinking biomolecules. This compound is essential for researchers and manufacturers in the pharmaceutical, biotechnology, and materials science industries developing advanced probes, sensors, and functional polymers.

Application

• Photoaffinity Labeling: A critical reagent for covalently capturing transient protein-ligand interactions and mapping binding sites in drug discovery.
• Bioorthogonal Chemistry: Used in Cu-free click reactions with alkynes for selective bioconjugation and live-cell imaging applications.
• Fluorescent Probe Synthesis: Acts as a precursor for developing turn-on or ratiometric fluorescent sensors and markers.
• Polymer & Material Science: Incorporated into polymer backbones or surfaces to introduce photo-crosslinkable or clickable functionalities.
• Chemical Biology Tool Development: Enables the study of enzyme mechanisms and metabolic pathways through targeted labeling.
• Pharmaceutical Intermediate: Serves as a key synthetic intermediate for novel active pharmaceutical ingredients (APIs) with coumarin scaffolds.

Basic Information

Product Name	4-Azidocoumarin
CAS No.	42373-56-8
Molecular Formula	C9H5N3O2
Molecular Weight	187.16 g/mol
Synonyms	4-Azido-2H-chromen-2-one; 4-Azido-1-benzopyran-2-one; 4-Azidocumarin; 4-Azido-coumarin; 4-N3-Coumarin; Azidocoumarin; 4-Azido-2H-1-benzopyran-2-one
EINECS	Contact for details

Quality Control

Our 4-Azidocoumarin is produced under strict quality management protocols. Each batch undergoes comprehensive analytical testing, including HPLC for purity and identity confirmation via FT-IR and NMR spectroscopy, to ensure it meets the high standards required for research and development. A detailed Certificate of Analysis (COA) is provided with every shipment, guaranteeing traceability and consistent batch-to-batch quality.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). Due to its light-sensitive nature and organic azide group, the material should be handled with appropriate care, avoiding prolonged exposure to light, heat, or strong oxidizers.

Specification

Item	Specification
Appearance	Yellow to light brown crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 95%
Melting Point	Contact for details
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.