Description

Methyl 3-(Trimethylsilyl)Propiolate CAS NO 42201-71-8 is a versatile organosilicon building block featuring both a silyl-protected acetylene and a methyl ester functional group. This bifunctional nature makes it a critical intermediate for the synthesis of complex molecules, particularly in advanced material science and pharmaceutical research. It is primarily utilized by R&D chemists and process development scientists in the pharmaceutical, agrochemical, and specialty chemical industries for constructing carbon-carbon bonds and introducing functionalized acetylene units into target compounds.

Application

• Pharmaceutical Intermediates: Key synthon for the preparation of active pharmaceutical ingredients (APIs) and complex heterocycles via Sonogashira and other cross-coupling reactions.
• Agrochemical Synthesis: Used in the development of novel pesticides and herbicides, leveraging the acetylene moiety for structural diversity.
• Material Science: Building block for polymers, dendrimers, and organic electronic materials where the silyl group aids in solubility and processability.
• Organic Synthesis: A protected acetylene equivalent for multi-step synthesis, allowing for selective deprotection and further functionalization.
• Ligand and Catalyst Development: Precursor for synthesizing specialized ligands used in homogeneous catalysis.
• Chemical Research: Valuable reagent in academic and industrial R&D for exploring new synthetic methodologies and reaction pathways.

Basic Information

Product Name	Methyl 3-(Trimethylsilyl)Propiolate
CAS No.	42201-71-8
Molecular Formula	C7H12O2Si
Molecular Weight	156.26 g/mol
Synonyms	Methyl 3-(Trimethylsilyl)prop-2-ynoate; Methyl Trimethylsilylpropiolate; Propiolic acid, 3-(trimethylsilyl)-, methyl ester; 3-(Trimethylsilyl)propynoic acid methyl ester; Methyl (trimethylsilyl)propiolate; TMS-propiolic acid methyl ester; Methyl β-(trimethylsilyl)propiolate
EINECS	Contact for details

Quality Control

Our production of Methyl 3-(Trimethylsilyl)Propiolate adheres to stringent quality management protocols to ensure batch-to-batch consistency and high purity. Each lot undergoes comprehensive analytical testing, including GC, HPLC, and NMR, to verify identity, potency, and impurity profiles. Certificates of Analysis (COA) documenting all specifications are provided with every shipment to support your quality assurance and regulatory needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated area at room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent moisture absorption and degradation.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR)	Conforms to structure
Purity (GC)	≥ 97.0%
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.