Description

Bromoacetic Acid n-Hydroxysuccinimide Ester is a highly reactive and versatile heterobifunctional crosslinking agent. This compound is critical for the site-specific conjugation of molecules, particularly in the synthesis of bioconjugates and functionalized polymers. It is an essential reagent for researchers and manufacturers in the pharmaceutical, biotechnology, and diagnostics industries who require precise and efficient coupling chemistry.

Application

• Bioconjugate Synthesis: Primary reagent for coupling peptides, proteins, or antibodies to other biomolecules, surfaces, or drug payloads.
• Affinity Chromatography Ligand Immobilization: Used to attach specific ligands to solid supports like agarose or sepharose beads for protein purification.
• Polymer Functionalization: Key intermediate for introducing reactive bromoacetyl groups into polymers, dendrimers, or nanoparticles for further modification.
• Diagnostic Assay Development: Employed in the preparation of enzyme-labeled antibodies or hapten-carrier protein conjugates for ELISA and other immunoassays.
• Prodrug and ADC (Antibody-Drug Conjugate) Linker Chemistry: Serves as a building block for constructing cleavable or non-cleavable linkers in targeted therapeutic agents.
• Surface Plasmon Resonance (SPR) Chip Coating: Facilitates the covalent immobilization of biomolecules on sensor chips for interaction analysis.
• Materials Science: Used to create crosslinked hydrogels or functionalized materials with specific biological activity.

Basic Information

Product Name	Bromoacetic Acid n-Hydroxysuccinimide Ester
CAS No.	42014-51-7
Molecular Formula	C6H6BrNO4
Molecular Weight	236.02 g/mol
Synonyms	N-Hydroxysuccinimide Bromoacetate; Bromoacetyl N-Hydroxysuccinimide Ester; Succinimidyl Bromoacetate; Bromoacetic Acid N-Hydroxysuccinimide Ester; Bromoacetoxysuccinimide; 2-Bromoacetic Acid 2,5-Dioxopyrrolidin-1-yl Ester; N-(Bromoacetyloxy)succinimide; BANHS
EINECS	Contact for details

Quality Control

Our Bromoacetic Acid n-Hydroxysuccinimide Ester is manufactured under strict quality controls to ensure high purity and batch-to-batch consistency, suitable for sensitive research and production applications. Each lot is accompanied by a comprehensive Certificate of Analysis (COA) detailing purity, identity, and impurity profiles. We adhere to relevant quality management standards to support our global customer base.

Storage

Preserve in a tightly closed container, protected from light. Store in a freezer at -20°C or below under desiccant. This product is hygroscopic (moisture-sensitive) and light-sensitive. Allow the sealed container to reach room temperature before opening to minimize moisture condensation. Store in a well-ventilated, dry place away from incompatible materials.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Melting Point	Contact for details
Water Content (KF)	≤ 0.5%
Solubility	Soluble in DMF, DMSO, acetonitrile

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.