Description

o-(tert-Butyldimethylsilyl)Hydroxylamine is a specialized organosilicon reagent featuring a protected hydroxylamine functional group. This compound is critically important as a versatile building block in organic synthesis, particularly for the controlled introduction of nitrogen and oxygen functionalities. It is primarily utilized by research chemists and process development scientists in the pharmaceutical, agrochemical, and advanced materials sectors for constructing complex molecular architectures.

Application

• Pharmaceutical Intermediate Synthesis: A key reagent for the preparation of oxime ethers, hydroxamic acids, and other nitrogen-oxygen containing pharmacophores.
• Peptide and Protein Modification: Used in the site-specific modification of biomolecules, enabling the study of protein function and the development of bioconjugates.
• Polymer Chemistry: Serves as a functional monomer or chain-transfer agent in the synthesis of specialty polymers with tailored surface properties.
• Asymmetric Synthesis: Employed in chiral auxiliary and catalyst systems for the stereoselective construction of C-N and C-O bonds.
• Material Science: Utilized in surface functionalization of silica and other inorganic materials to alter wettability and adhesion properties.
• Agrochemical Development: Acts as a precursor in the synthesis of novel herbicides, fungicides, and plant growth regulators.

Basic Information

Product Name	o-(tert-Butyldimethylsilyl)Hydroxylamine
CAS No.	41879-39-4
Molecular Formula	C6H17NOSi
Molecular Weight	147.29 g/mol
Synonyms	O-(tert-Butyldimethylsilyl)hydroxylamine; N-(tert-Butyldimethylsilyloxy)amine; TBDMS-hydroxylamine; tert-Butyldimethylsilyl hydroxyl ether; Hydroxylamine O-(tert-butyldimethylsilyl) ether; O-TBDMS-hydroxylamine; N-(tert-Butyldimethylsiloxy)amine; O-(tert-Butyldimethylsilyl)hydroxyamine
EINECS	Contact for details

Quality Control

Our o-(tert-Butyldimethylsilyl)Hydroxylamine is produced under strict quality management protocols to ensure batch-to-batch consistency and high purity, suitable for demanding research and scale-up applications. Each lot is accompanied by a comprehensive Certificate of Analysis (COA) detailing purity, identity, and impurity profiles. We support compliance with cGMP and ICH guidelines for pharmaceutical development.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed under an inert atmosphere (argon or nitrogen) after opening to prevent moisture absorption and degradation.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR)	Conforms
Purity (GC/HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.