Description

Spiro[Cyclopropane-1,9'-[9H]Fluorene]-2α,3α-Dicarboxylic Acid Diethyl Ester is a high-purity, specialized organic building block featuring a unique spirocyclic and fluorene-based molecular architecture. This compound matters as a critical chiral intermediate for synthesizing complex molecules in advanced pharmaceutical and materials research, offering precise stereochemical control. It is essential for R&D chemists and process development scientists working in pharmaceutical discovery, agrochemical development, and the creation of novel organic electronic materials.

Application

• Pharmaceutical Intermediate: Key chiral synthon for the development of novel active pharmaceutical ingredients (APIs), particularly in central nervous system (CNS) and anti-inflammatory drug candidates.
• Agrochemical Synthesis: Serves as a precursor for advanced crop protection agents and pesticides, leveraging its complex, rigid spirocyclic structure.
• Organic Electronic Materials: A valuable monomer or precursor for developing organic semiconductors, hole-transport materials, or light-emitting materials in OLED and OPV applications.
• Asymmetric Catalysis Ligand Precursor: Used in the synthesis of sophisticated chiral ligands for asymmetric hydrogenation and C-C bond formation reactions.
• Academic & Industrial R&D: A versatile scaffold in medicinal chemistry for structure-activity relationship (SAR) studies and library synthesis.
• Fine Chemical Production: Employed in the multi-step synthesis of other high-value, complex fine chemicals and flavors/fragrances.

Basic Information

Product Name	Spiro[Cyclopropane-1,9'-[9H]Fluorene]-2α,3α-Dicarboxylic Acid Diethyl Ester
CAS No.	41411-72-7
Molecular Formula	C22H20O4
Molecular Weight	348.40 g/mol
Synonyms	Diethyl Spiro[cyclopropane-1,9'-fluorene]-2α,3α-dicarboxylate; 9H-Fluorene-9-spirocyclopropane-2α,3α-dicarboxylic Acid Diethyl Ester; Spiro(cyclopropane-1,9'-fluorene)-2α,3α-dicarboxylic Acid, Diethyl Ester; 2α,3α-Di(ethoxycarbonyl)spiro[cyclopropane-1,9'-fluorene]; Ethyl Spiro[cyclopropane-1,9'-fluorene]-2α,3α-dicarboxylate; Spirofluorenecyclopropane Diethyl Ester
EINECS	Contact for details

Quality Control

Every batch of Spiro[Cyclopropane-1,9'-[9H]Fluorene]-2α,3α-Dicarboxylic Acid Diethyl Ester is manufactured under strict quality management systems. Our products undergo rigorous quality testing, including chiral purity analysis, to ensure compliance with exacting R&D and process chemistry standards. A comprehensive Certificate of Analysis (COA) detailing identity, purity, and impurity profiles is provided with each shipment and is available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at a controlled room temperature (15-25°C). Keep away from strong alkalis and incompatible organic solvents. For long-term storage, consider an inert atmosphere to maintain optimal purity.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Chiral Purity (Chiral HPLC)	≥ 99.0% ee
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%
Single Unknown Impurity (HPLC)	≤ 0.5%
Total Impurities (HPLC)	≤ 2.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.