Description

2-Chloro-5-Hydroxypyridine is a versatile halogenated pyridine derivative that serves as a critical building block in advanced organic synthesis. Its bifunctional nature, featuring both a reactive chloro substituent and a hydroxyl group, makes it a valuable intermediate for constructing complex molecular architectures. This compound is essential for research and development chemists in the pharmaceutical, agrochemical, and specialty chemical industries seeking to develop new active ingredients and functional materials.

Application

• Pharmaceutical Intermediate: Key precursor in the synthesis of active pharmaceutical ingredients (APIs), particularly for drugs targeting the central nervous system and anti-infectives.
• Agrochemical Synthesis: Used in the manufacture of advanced herbicides, fungicides, and insecticides, where the pyridine core contributes to biological activity.
• Ligand and Catalyst Development: Serves as a starting material for creating novel chelating ligands and organocatalysts used in asymmetric synthesis and metal complexation.
• Material Science: Building block for the production of functional polymers, liquid crystals, and organic electronic materials.
• Chemical Research: Valuable scaffold in medicinal chemistry for structure-activity relationship (SAR) studies and library synthesis.

Basic Information

Product Name	2-Chloro-5-Hydroxypyridine
CAS No.	41288-96-4
Molecular Formula	C5H4ClNO
Molecular Weight	129.54 g/mol
Synonyms	5-Hydroxy-2-chloropyridine; 2-Chloro-5-pyridinol; 2-Chloro-5-pyridinone (tautomer); 5-Chloro-2-pyridone; 2-Chloro-5-hydroxypyridine; 2-Chloro-5-pyridinol; 2-Chloro-5-oxo-1,2-dihydropyridine; 2-Chloro-5-pyridone
EINECS	Contact for details

Quality Control

Our 2-Chloro-5-Hydroxypyridine is manufactured under a strict quality management system. Every batch undergoes comprehensive analytical testing, including HPLC for purity and identity confirmation via FT-IR and NMR spectroscopy, to ensure it meets the high standards required for synthetic applications. A detailed Certificate of Analysis (COA) documenting purity, assay, and impurity profiles is provided with each shipment to guarantee traceability and consistency for your critical processes.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated area at controlled room temperature (15-25°C). Keep away from incompatible materials such as strong oxidizing agents and strong bases. The container should be kept tightly sealed to protect from moisture.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Melting Point	158 - 162 °C
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.